Synthesis and conformational structure of hydrazo-bridged homo calix[2]pyridine[2]triazines was written by Liang, Dong-Dong;Wang, Mei-Xiang. And the article was included in Organic Chemistry Frontiers in 2017.Reference of 60221-37-6 This article mentions the following:
The practical synthesis and conformational structure of hydrazo-bridged homo calix[4]arenes I (R = Bu, 1-butyl-pentyl, 2-(2-[2-(oxan-2-yloxy)ethoxy]ethoxy)ethyl; X = H, Me) are presented. The step-wise fragment coupling method based on the nucleophilic aromatic substitution reaction of 2,6-dihydrazinylpyridine with 6-alkoxy-2,4-dichlorotriazine e.g., 2-butoxy-4,6-dichlorotriazine afforded effectively hydrazo-linked homo calix[2]pyridine[2]triazines I (R = Bu, 1-butyl-pentyl, 2-(2-[2-(oxan-2-yloxy)ethoxy]ethoxy)ethyl; X = H). The exhaustive methylation of -NHNH- linkages led to lipophilic macrocycles, while the introduction of a THP-protected triglyme moiety on a triazine ring produced a water soluble hydrazo-bridged homo calix[2]pyridine[2]triazine I R = (2-(2-[2-(oxan-2-yloxy)ethoxy]ethoxy)ethyl; X = H). The acquired hydrazo-bridged homo calix[4]arenes I adopted a cone conformational structure with two nitrogen atoms of the hydrazine linkage forming resp. a conjugation system with pyridine and triazine rings. The unique macrocyclic conformation and multidentate binding sites would render hydrazo-bridged homo calix[2]pyridine[2]triazines powerful hosts in mol. recognition and self-assembly. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Reference of 60221-37-6).
2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 60221-37-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem