NH4Cl-mediated new protocol for the synthesis of 5-arylidene barbiturates was written by Khan, Khalid Mohammed;Ali, Muhammad;Khan, Momin;Taha, Muhammad;Perveen, Shahnaz. And the article was included in Letters in Organic Chemistry in 2011.Electric Literature of C8H8O3 This article mentions the following:
Eco-benign method for synthesizing arylidene barbiturates was developed by using NH4Cl in stoichiometric amount, as an enolization activator, in water. Execution of methodol. is simple, products obtained in high yields and the reactions are completed within 30 min. The new methodol. does not involve any solvent/solvent extraction while solid products were yielded in all cases which were filtered and washed. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Electric Literature of C8H8O3).
3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Electric Literature of C8H8O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem