Chakravarti, D. et al. published their research in Science and Culture in 1938 | CAS: 6972-61-8

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 6972-61-8

Synthesis of coumarins from o-hydroxyaryl alkyl ketones was written by Chakravarti, D.;Majumdar, B.. And the article was included in Science and Culture in 1938.HPLC of Formula: 6972-61-8 This article mentions the following:

In attempting to synthesize naturally occurring coumarins by the method described it was found that (1) when there are 2 alkyl substituents in the 浼? and 灏?positions of the expected cinnamic acid, cis-cinnamic acid is formed and the coumarin is obtained in quant. yield; (2) when there is no substituent in these positions, trans-cinnamic acid is formed and ring closure does not take place to form a coumarin; (3) when only the 浼?position is occupied, trans-cinnamic acid is formed and the coumarin is not formed by ring closure. Thus o-MeOC6H4CHO condenses with BrCH2CO2Et, giving Et 2-methoxy-trans-cinnamate, b8 150鎺? which on hydrolysis yields 2-methoxy-trans-cinnamic acid, m. 182鎺? identical with the compound prepared from o-coumaric acid. Similarly o-MeOC6H4CHO and MeCHBrCO2Et yield Et 2-methoxy-浼?methylcinnamate, b4 155鎺? which on hydrolysis produces the acid trans-2-methoxy-浼?methylcinnamic acid, identical with the compound described by Perkin (J. Chem. Soc. 31, 415). 灏?Resorcylaldehyde di-Me ether and BrCH2CO2Et give Et 2,4-dimethoxy-trans-cinnamate, b8 184鎺? which on hydrolysis gives the 2,4-dimethoxy-trans-cinnamic acid of Perkin and Schiess (J. Chem. Soc. 85, 162). Et 2-methoxy-trans-cinnamate, Et 2-methoxy-浼?methyl-trans-cinnamate and Et 2,4-dimethoxy-trans-cinnamate do not give the expected coumarin derivatives on heating with HI. The method developed is useful in the synthesis of 3,4-dialkylated coumarin derivatives In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem