Mild and regioselective iodination of electron-rich aromatics with N-iodosuccinimide and catalytic trifluoroacetic acid was written by Castanet, Anne-Sophie;Colobert, Francoise;Broutin, Pierre-Emmanuel. And the article was included in Tetrahedron Letters in 2002.SDS of cas: 75581-11-2 This article mentions the following:
A variety of aromatic compounds substituted with methoxy or Me groups were regioselectively iodinated with N-iodosuccinimide and catalytic HO2CCF3 with excellent yields under mild conditions and short reaction times. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2SDS of cas: 75581-11-2).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C闂佺偨鍎茶ぐ濠囨煃閵夛箑鐤?linkages. In dimethyl ether, the bond angle is 111闁?and C闂佺偨鍎茶ぐ?distances are 141 pm. The barrier to rotation about the C闂佺偨鍎茶ぐ?bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.SDS of cas: 75581-11-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem