Interception of Nickel Hydride Species and Its Application in Multicomponent Reactions was written by Balakrishnan, Venkadesh;Ganguly, Anirban;Rasappan, Ramesh. And the article was included in Organic Letters in 2022.Category: ethers-buliding-blocks This article mentions the following:
The hydrogen borrowing strategy is an economical method for the 浼?functionalization of ketones. While this strategy is extremely advantageous, it does not lend itself to the synthesis of 灏?灏?disubstituted ketones. This can be achieved, if the in situ generated metal hydride can be intercepted with a nucleophilic coupling partner. Authors present a multicomponent strategy for the coupling of alcs., ketones, and boronic acids using only 1 mol % nickel catalyst and without the need for added ligands. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Category: ethers-buliding-blocks).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem