Ruthenium(II)/N-Heterocyclic Carbene Catalyzed [3+2] Carbocyclization with Aromatic N-H Ketimines and Internal Alkynes was written by Zhang, Jing;Ugrinov, Angel;Zhao, Pinjing. And the article was included in Angewandte Chemie, International Edition in 2013.HPLC of Formula: 16356-02-8 This article mentions the following:
A ruthenium(II)-catalyzed C-H functionalization by tandem imine-directed C-H bond activation and [3+2]-carbocyclization with internal alkynes to give indenamines, e.g., I, was reported. The reaction proceeded in general at room temperature and without the use of either strong oxidants or acid/base additives. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8HPLC of Formula: 16356-02-8).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 16356-02-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem