A scale-up procedure to dialkyl carbonates; evaluation of their properties, biodegradability, and toxicity was written by Trapasso, Giacomo;Salaris, Claudio;Reich, Marco;Logunova, Evgenia;Salata, Cristiano;Kummerer, Klaus;Figoli, Alberto;Arico, Fabio. And the article was included in Sustainable Chemistry and Pharmacy in 2022.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:
In this work, a scale-up procedure to non-com. available or expensive dialkyl carbonates via transcarbonylation reaction of an alc. with di-Me carbonate promoted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was explored. DACs selected for this study include sym. and unsym. compounds incorporating alkyl, alkoxyalkyl, aminoalkyl, and thioalkyl moieties. Compared to previously published works, the proposed procedure was customized for large-scale production of DACs (up to 100 mL); purification of the products was achieved by distillation, and recycling of the exceeding reagents was addressed. Furthermore, the role of the catalyst was investigated, and a possible reaction mechanism proposed. The chem.-phys. properties of the new DACs were evaluated employing softwares and models based on quant. structure-activity relationships (QSAR). Biodegradability and toxicity tests was also carried out both exptl. and by computational studies so to investigate the effect of the sulfur, nitrogen, or oxygen-containing moieties on the greenness of these – in some cases new -solvents and reagents. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2-(2-Methoxyethoxy)ethanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem