An efficient entry to pyrrolo[1,2-b]isoquinolines and related systems through Parham cyclization was written by Ruiz, Javier;Ardeo, Ainhoa;Ignacio, Roberto;Sotomayor, Nuria;Lete, Esther. And the article was included in Tetrahedron in 2005.Category: ethers-buliding-blocks This article mentions the following:
Aryllithiums generated by lithium-iodine exchange underwent intramol. cyclization to give pyrrolo[1,2-b]isoquinolines, e.g, I, in high yields. The best results were obtained when Weinreb or morpholine amides were used as internal electrophiles. The procedure has been extended to the preparation of seven and eight membered rings, opening a route to benzazepine and benzazocine skeletons. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem