Lee, Na-Ra et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2019 | CAS: 3929-47-3

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 – M5 muscarinic acetylcholine receptors was written by Lee, Na-Ra;Gujarathi, Satheesh;Bommagani, Shobanbabu;Siripurapu, Kiranbabu;Zheng, Guangrong;Dwoskin, Linda P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Category: ethers-buliding-blocks This article mentions the following:

Quinuclidinyl N-phenylcarbamates and azabicyclic (arylethyl)phenylcarbamates such as I [R = 4-FC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3] were prepared as ligands for the human M5 muscarinic acetylcholine receptor (mAChR) for potential use in the treatment of drug abuse and chronic obstructive pulmonary disease; their binding to M1-M5 mAChR were determined I (R = 4-FC6H4) exhibited the highest affinities for M1-M5 mAChR (Ki = 2.0, 13, 2.6, 2.2, 1.8 nM for M1, M2, M3, M4, M5 mAChR, resp.) of the tested ligands but was not selective for a single mAChR subtype. I (R = 4-FC6H4) acted as an agonist at mAChRs; the effect of I (R = 4-FC6H4) was inhibited by the nonselective mAChR antagonist scopolamine, and I (R = 4-FC6H4) augmented the release of dopamine evoked by oxotremorine. I (R = 4-MeOC6H4) was 17-fold selective for M3 mAChR over M2 mAChR. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem