Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates was written by Kanemoto, Kazuya;Sakata, Yuki;Hosoya, Takamitsu;Yoshida, Suguru. And the article was included in Chemistry Letters in 2020.Recommanded Product: 112-49-2 This article mentions the following:
Novel synthetic methods for phenoxathiins e.g., I and phenothiazines II (R = H, OMe, morpholin-4-yl, etc.) by aryne reactions e.g., 2-(trimethylsilyl)phenyl triflate are disclosed. Here, it was found that phenoxathiins e.g., I were efficiently prepared by the reaction between aryne intermediates and S-(2-hydroxyaryl) 4-toluenethiosulfonates R1-2-OHC6H3STs (R1 = H, 5-Me, 4-OMe). A synthetic method for phenothiazines II was also developed by the reaction of arynes with S-(2-aminophenyl)-4-toluenethiosulfonate. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Recommanded Product: 112-49-2).
2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 112-49-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem