Synthesis of 3,3-diarylpropionic acids using phosphoric acid as catalyst was written by Elsworth, J. F.;Lamchen, M.. And the article was included in Journal of the South African Chemical Institute in 1972.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:
Phenols and their Me ethers, in the presence of 85% H3PO4, readily add to the β-C atom of cinnamic acids bearing a MeO group in either the ortho or para positions on the phenyl group, to give high yields of 3,3-diarylpropionic acids. If an ortho HO group is present on the addend, the propionic acid can lactonize to yield a 4-aryldihydrocoumarin. The product from addition of 2,4-dimethoxycinnamic acid to anisole is capable reacting nucleophilically with more 2,4-dimethoxycinnamic acid to yield a bispropionic acid. A truxillic acid is obtained when 3,4-dimethoxycinnamic acid is either warmed with H3PO4 or shaken with m-xylene in the presence of H3PO4. The methoxycinnamic acid is initially protonated by H3PO4 and the derived quinonoid structure is susceptible to attack by nucleophiles. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem