High hypolipidemic activity of saturated side-chain α-asarone analogs was written by Cruz, Adriana;Garduno, Leticia;Salazar, Maria;Martinez, Elizdath;Diaz, Francisco;Chamorro, German;Tamariz, Joaquin. And the article was included in Medicinal Chemistry Research in 2001.SDS of cas: 3929-47-3 This article mentions the following:
With the aim of evaluating the pharmacophore potential of the side chain of α-asarone regarding its high hypolipidemic activity, α-asarone analogs (I) were evaluated pharmacol. For I, with a variable-size side chain, significant decreases in serum cholesterol, LDL-cholesterol, and triglyceride levels and significant increases in HDL-cholesterol levels were observed in mice. I were even more active than α-asarone in reducing cholesterol. The results suggested that the length and saturated character of the side chain seem to be a key feature in improving hypolipidemic activity of I. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3SDS of cas: 3929-47-3).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.SDS of cas: 3929-47-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem