Oxadiazinones as chiral auxiliaries: increased diastereoselectivities in the glycolate aldol reaction of oxadiazinones was written by Vaughn, Jeremy F.;Hitchcock, Shawn R.. And the article was included in Tetrahedron: Asymmetry in 2004.Application of 1877-75-4 This article mentions the following:
Glycolate aldol reactions were conducted using a (1R,2S)-norephedrine based N4-isopropyloxadiazinone as a chiral template to afford aldol adducts. The yields ranged from 57% to 99% while the diastereoselectivities ranged from 94:6 to 99:1. One adduct was hydrolyzed to afford an oxadiazinone auxiliary and β-hydroxy acid, which was converted to the known Me (2S,3R)-2,3-dihydroxy-3-phenylpropionate with 95% ee as determined by chiral HPLC. Studies directed toward the synthesis if HIV protease inhibitors nelfinavir and saquinavir are underway. One of the chiral auxiliaries thus prepared was (-)-(5S,6R)-tetrahydro-3-[(4-methoxyphenoxy)acetyl]-5-methyl-4-(1-methylethyl)-6-phenyl-2H-1,3,4-oxadiazin-2-one (I). In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application of 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem