Improved synthesis of natural ester sintenin and its analogues via Wittig reaction was written by Sharma, Mukul;Rajesh, U. Chinna;Rawat, Diwan S.. And the article was included in Journal of the Indian Chemical Society in 2013.Formula: C11H16O3 This article mentions the following:
The synthesis of a cytotoxic natural ester sintenin and twenty eight analogs including nitrogen-containing heterocyclic indole groups, saturated amides and unsaturated amides was carried out by a convenient one-pot Wittig reaction in aqueous medium with improved yield. A systematic structure activity relationship of sintenin ester was designed by chem. modified derivatives in order to get better cytotoxicity. The title compounds thus formed included 3,4-Dimethoxybenzenepropanoic acid 3-(3,4-dimethoxyphenyl)propyl ester (sintenin carboxylic acid ester) (I) and related substances. The synthesis of the target compounds was achieved by a reaction of benzenepropanoic acid derivatives with benzenepropanol derivatives Wittig reaction products included (2E)-3-(phenyl)-2-propenoic acid derivatives and (2E)-3-(phenyl)-2-propen-1-ol derivatives Amide analogs were prepared from (2E)-3-phenyl-2-propen-1-amine. Amide analogs thus formed included (2E)-3-(4-methylphenyl)-N-(3-phenylpropyl)-2-propenamide, 4-methyl-N-(3-phenylpropyl)benzenepropanamide. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Formula: C11H16O3).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Formula: C11H16O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem