Combinatorial approach for the design of new, simplified chiral phase-transfer catalysts with high catalytic performance for practical asymmetric synthesis of α-alkyl-α-amino acids was written by Kitamura, Masanori;Arimura, Yuichiro;Shirakawa, Seiji;Maruoka, Keiji. And the article was included in Tetrahedron Letters in 2008.Application of 66943-05-3 This article mentions the following:
A very efficient, chiral phase-transfer catalyst, quaternary ammonium salt I, was prepared from the easily available (S)-1,1′-binaphthyl-2,2′-dicarboxylic acid. I exhibited the high catalytic activity (0.01-0.1 mol %) in the asym. alkylation of N-(diphenylmethylene)glycine tert-Bu ester compared to other existing chiral phase-transfer catalysts. This catalyst will be useful in the enantioselective synthesis of structurally diverse natural and unnatural α-alkyl-α-amino acids. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Application of 66943-05-3).
1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 66943-05-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem