Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines was written by Khan, Imtiaz;Zaib, Sumera;Ibrar, Aliya;Rama, Nasim Hasan;Simpson, Jim;Iqbal, Jamshed. And the article was included in European Journal of Medicinal Chemistry in 2014.SDS of cas: 1877-75-4 This article mentions the following:
Nitrogen-containing heterocycles are of particular interest and significant importance for the discovery of potent bioactive agents in pharmaceutical industry. The present study reports the synthesis of a library of new conjugated heterocycles including I [R1 = 4-FC6H4OCH2, 2-furyl, 3-furyl, etc.] and II [R2 = 3-ClC6H4, 4-biphenyl, 1-naphthyl, etc.] by cyclocondensation reaction of 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with various substituted aromatic acids and phenacyl bromides, resp. The structures of newly synthesized compounds were characterized by elemental anal., IR, 1H and 13C NMR spectroscopy and in case of I [R1 = 2-furyl] by x-ray crystallog. anal. Newly synthesized triazolothiadiazoles and thiadiazines were screened for acetyl- and butyryl-cholinesterases and alk. phosphatase inhibition. Almost all of the compounds showed good to excellent activities against acetylcholinesterase more than the reference drugs. Compound I [R1 = 4-MeOC6H4OCH2] exhibited IC50 value 0.77±0.08 μM against acetylcholinesterase and I [R1 = 2-F-4-Cl-C6H3] showed IC50 9.57±1.42 μM against butyrylcholinesterase. Among all the tested compounds, I [R1 = 2-F-4-Cl-C6H3] also proved as excellent inhibitor of alk. phosphatase with IC50 0.92±0.03 μM. These heteroaromatic hybrid structures were also tested for their anticancer activity against lung carcinoma (H157) and kidney fibroblast (BHK-21) cell lines and leishmanias. Variable cell growth inhibitory activities were obtained and many compounds exhibit potent %inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4SDS of cas: 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.SDS of cas: 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem