Identification, isolation and characterization of potential degradation product in idebenone drug substance was written by Ramulu, K.;Rao, B. M.;Rao, N. Someswara. And the article was included in Rasayan Journal of Chemistry in 2013.Category: ethers-buliding-blocks This article mentions the following:
In the stress degradation studies of Idebenone, one major unknown base degradation impurity was identified by LC-MS. This impurity was isolated using preparative high performance liquid chromatog. Based on the spectral data (1H NMR, 13C NMR, DEPT, MS, HR-MS and IR), this degradation impurity is characterized as 2-hydroxy-5-(10-hydroxydecyl)-3-methoxy-6-methylcyclohexa-2,5-diene-1,4-dione. The details of stress studies, identification, isolation, characterization, formation and mechanism of this impurity is discussed and presented in detail. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Category: ethers-buliding-blocks).
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem