A reusable MOF supported single-site nickel-catalyzed direct N-alkylation of anilines with alcohols was written by Lu, Yuanyuan;Chai, Huining;Yu, Kun;Huang, Chaonan;Li, Yujie;Wang, Jinyu;Ma, Jiping;Tan, Weiqiang;Zhang, Guangyao. And the article was included in Tetrahedron in 2022.Electric Literature of C8H10O2 This article mentions the following:
A highly selective and reusable Ni(II)-bipyridine-based metal-organic framework (MOF) catalyst was designed for direct N-alkylation of amines with alcs. through a borrowing hydrogen (BH) strategy. This earth-abundant metal-based metal-organic framework catalyst significantly outperforms its homogeneous analogs and is reusable for at least up to 4 cycles without significant decrease in the yield of the target product. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Electric Literature of C8H10O2).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Electric Literature of C8H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem