Synthetic analogs of Peganum alkaloids. 1. Synthesis of methoxy- and hydroxysubstituted desoxyvasicinones and desoxypeganines was written by Karimov, A.;Telezhenetskaya, M. V.;Yunusov, S. Yu.. And the article was included in Khimiya Prirodnykh Soedinenii in 1982.Safety of 3-Methyl-4-nitroanisole This article mentions the following:
Cyclocondensation of methoxyanthranilic acids with 2-pyrrolidinone in the presence of POCl3 or SOCl2 gave the methoxydeoxyvasicinones I (R = MeO; Z = O), which were treated with 47% HBr to give I (R = HO; Z = O). Zn reduction of I (Z = O) gave deoxypeganines I (Z = H2). In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Safety of 3-Methyl-4-nitroanisole).
3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Safety of 3-Methyl-4-nitroanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem