Continuous-Flow Synthesis of Perfluoroalkyl Ketones via Perfluoroalkylation of Esters Using HFC-23 and HFC-125 under a KHMDS-Triglyme System was written by Fujihira, Yamato;Iwasaki, Hiroto;Sumii, Yuji;Adachi, Hiroaki;Kagawa, Takumi;Shibata, Norio. And the article was included in Bulletin of the Chemical Society of Japan in 2022.Reference of 112-49-2 This article mentions the following:
Herein, a method for the chem. transformation of two HFCs, viz was described. HFC-23 and HFC-125, based on the continuous-flow perfluoroalkylation of esters to synthesize the pharmaceutically and agrochem. vital trifluoromethyl and pentafluoroethyl ketones. The combination of a potassium base and a glyme solvent system was found to be the most effective. The proposed method was attractive for industrial use because it allows the consumption of a large volume of HFCs, promotes the synthesis of high-value medicinal compounds, and serves as an ideal alternative to the current HFC decomposition processes like thermal plasma treatment. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Reference of 112-49-2).
2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 112-49-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem