Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile-nucleophile dual activation by [Omim]Br for the reaction was written by Zhang, Xiao;Lu, Guo-ping;Cai, Chun. And the article was included in Green Chemistry in 2016.Application of 54916-28-8 This article mentions the following:
A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chem. provides an efficient and metal-free approach for the generation of Caryl-X (X=S, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodol. attractive to both synthetic and medicinal chem. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application of 54916-28-8).
1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 54916-28-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem