Urethanes synthesis from oxamic acids under electrochemical conditions was written by Ogbu, Ikechukwu Martin;Lusseau, Jonathan;Kurtay, Gulbin;Robert, Frederic;Landais, Yannick. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:
Urethane RHNC(O)OR1 [R = cyclohexyl, Bn, CH2CH2Ph, etc.; R1 = Me, Et, CH2CF3, etc.] and R2OC(O)NHCHR3C(O)OMe [R2 = Me, Et, CH2CH=CH2, CH2CF3, CH2CH(CH3)2; R3 = Me, CH2CO2Me, Ph] synthesis via oxidative decarboxylation of oxamic acids under mild electrochem. conditions was reported. This simple phosgene-free route to urethanes involved an in situ generation of isocyanates by anodic oxidation of oxamic acids in an alc. medium. The reaction was applicable to a wide range of oxamic acids, including chiral ones, and alcs. furnishing the desired urethanes in a one-pot process without the use of a chem. oxidant. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 2-(2-Methoxyethoxy)ethanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem