Characterization of volatile compounds of Albertisia papuana Becc root extracts and cytotoxic activity in breast cancer cell line T47D was written by Kristiani, Elizabeth B. E.;Nugroho, Laurentius H.;Moeljopawiro, Sukarti;Widyarini, Sitarina. And the article was included in Tropical Journal of Pharmaceutical Research in 2016.Recommanded Product: 56619-93-3 This article mentions the following:
Purpose: To evaluate the cytotoxic activity of chloroform and water root extracts of Albertisia papuana Becc. on T47D cell line and identify the volatile compounds of the extracts Methods: The plant roots were extracted with chloroform and water using maceration and boiling methods, resp. The cytotoxicity of the extracts on T47D were determined using 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Doxorubicin was used as reference drug in the cytotoxicity test while Probit anal. was used to calculate the Median Growth Inhibitory Concentration IC50 of the extracts The volatile compounds in the chloroform and water root extracts were analyzed using Gas Chromatog.-Mass Spectrophotometry GC-MS. Results: The IC50 of the chloroform and water extracts were 28.0 ± 6.0 and 88.0 ± 5.5μg/mL, resp. whereas that of doxorubicin was 8.5 ± 0.1μg/mL. GC-MS results showed that there were 46 compounds in the chloroform extract, out of which the five major components are Et linoleate (49.68%), bicyclo (3.3.1) non-2-ene (29.29%), Et palmitate (5.06%), palmitic acid (3.67%) and Et heptadecanoate (1.57%).The water extract consisted of three compounds, butanoic acid (15.58%); Me cycloheptane (3.45%), and Me 2-O-methylpentofuranoside (80.96%). Conclusion: The chloroform root extract of A. papuana Becc. had a fairly potent anticancer activity against breast cancer cells and may be further developed as an anticancer agent. Its major components were fatty acids and fatty acid esters. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem