Tuning Zr(IV)-assisted peptide hydrolysis at near-neutral pH was written by Kassai, Miki;Grant, Kathryn B.. And the article was included in Inorganic Chemistry Communications in 2008.Synthetic Route of C10H21NO4 This article mentions the following:
The present study has compared the effects of a total of 17 ligands on Zr(IV)-assisted hydrolysis of dipeptide Gly-Gly (60°, pH 6.8-7.4, t = 4, 10 h). The macrocyclic azacrown ether ligands 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and 1,4,10-trioxa-7,13-diazacyclopentadecane produced the overall highest amounts of hydrolysis, followed by the open-chain ligand 2-(2-aminoethoxy)ethanol. While it was not necessary to have a ring structure to enhance Zr(IV) reactivity, the structural feature “ROCH2CH2OCH2CH2NR” in ligands appeared to contribute to increased levels of peptide cleavage. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).
1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Synthetic Route of C10H21NO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem