Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity was written by Jang, Mi-Yeon;Lin, Yuan;De Jonghe, Steven;Gao, Ling-Jie;Vanderhoydonck, Bart;Froeyen, Mathy;Rozenski, Jef;Herman, Jean;Louat, Thierry;Van Belle, Kristien;Waer, Mark;Herdewijn, Piet. And the article was included in Journal of Medicinal Chemistry in 2011.Product Details of 1877-75-4 This article mentions the following:
The synthesis and in vitro and in vivo activity of thiazolo[5,4-d]pyrimidines, e.g., I as a novel class of immunosuppressive agents, useful for preventing graft rejection after organ transplantation is described. This research resulted in the discovery of a series of compounds with potent activity in the mixed lymphocyte reaction (MLR) assay, which is well-known as the in vitro model for in vivo rejection after organ transplantation. The most potent congeners displayed IC50 values of less than 50 nM in this MLR assay and hence are equipotent to cyclosporin A, a clin. used immunosuppressive drug. One representative of this series was further evaluated in a preclin. animal model of organ transplantation and showed excellent in vivo efficacy. It validates these compounds as new promising immunosuppressive drugs. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Product Details of 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Product Details of 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem