Convenient and flexible syntheses of gem-dimethyl carboxylic triggers via mono-selective β-C(sp3)-H arylation of pivalic acid with ortho-substituted aryl iodides was written by Huang, Yongliang;Du, Yu;Su, Weiping. And the article was included in Organic Chemistry Frontiers in 2022.Safety of 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:
This work presents a palladium(II)-catalyzed mono-selective C(sp3)-H arylation of pivalic acid for rapid construction of an important library of 3-aryl-2,2-dimethylpropanoic acids, especially ortho-substituted-aryl compounds The strategy greatly streamlines access to a series of trimethyl-lock-type triggers – arylated gem-di-Me carboxylic acids bearing ortho-activatable substituents, which was used as a self-immolative spacer for selective chem. release initiated under specific conditions. Flexible transformation and derivatization of these activatable carboxylic triggers were also showcased. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Safety of 4-Iodo-1-methoxy-2-methylbenzene).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 4-Iodo-1-methoxy-2-methylbenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem