Habibi-Yangjeh, Aziz et al. published their research in Indian Journal of Chemistry in 2007 | CAS: 1877-75-4

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Prediction of acidity constant for substituted acetic acids in water using artificial neural networks was written by Habibi-Yangjeh, Aziz;Danandeh-Jenagharad, Mohammad. And the article was included in Indian Journal of Chemistry in 2007.Category: ethers-buliding-blocks This article mentions the following:

Linear and non-linear quant. structure-activity relationships have been successfully developed for the modeling and prediction of acidity constant (pKa) of 87 substituted acetic acids with diverse chem. structures. The descriptors appearing in the multi-parameter linear regression (MLR) model are considered as inputs for developing the back-propagation artificial neural network (BP-ANN). ANN model is constructed using two mol. descriptors; the most pos. charge of acidic hydrogen atom (Q+) and most neg. charge of the carboxylic oxygen atom (q–) as inputs and its output is pKa. It has been found that properly selected and trained neural network with 53 substituted acetic acids could fairly represent dependence of the acidity constant on mol. descriptors. For evaluation of the predictive power of the generated ANN, an optimized network has been applied for prediction pKa values of 17 compounds in the prediction set. Mean percentage deviation (MPD) for prediction set using the MLR and ANN models are 9.135 and 1.362, resp. These improvements are due to the fact that the pKa of substituted acetic acids demonstrates non-linear correlations with the mol. descriptors. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Category: ethers-buliding-blocks).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem