Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile was written by Alix, Florent;Gembus, Vincent;Coquet, Laurent;Hubert-Roux, Marie;Chan, Philippe;Truong, Lina;Sebban, Muriel;Coadou, Gael;Oulyadi, Hassan;Papamicael, Cyril;Levacher, Vincent. And the article was included in ACS Omega in 2018.Recommanded Product: 56619-93-3 This article mentions the following:
The (dimethylcarbamoyloxy)dihydroquinolinecarboxamide I, a prodrug for an irreversible inhibitor of acetylcholinesterase (AChE), was prepared on multigram scale in nine steps and 18% overall yield from m-anisidine. The conversion of I to the active (carbamoyloxy)(methylaminocarbonyl)quinolinium was observed in vitro; O-dimethylcarbamoylated human AChE was detected and sequenced using tandem mass spectrometry to determine the site of dimethylcarbamoylation, and the kinetics of dimethylcarbamoylation were determined The physicochem. properties of I, its selectivity for AChE over other enzymes, and its inhibition of cytochrome P450 isoenzymes and hERG and NaV1.5 ion channels, and its toxicity in rats were determined In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem