Synthesis of Polysubstituted 3-Methylisoquinolines through the π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine was written by Vargas, Didier F.;Larghi, Enrique L.;Kaufman, Teodoro S.. And the article was included in European Journal of Organic Chemistry in 2018.Safety of 3-Hydroxy-5-methoxybenzaldehyde This article mentions the following:
A convenient one pot microwave-assisted π-electron cyclization/aromatization approach for the synthesis of 3-methylisoquinolines I [R1 = H, Me; R2 = R3 = R4 = H, OMe; R5 = H, Me, Bn, etc.] was reported. The starting 1-azatriene derivatives were prepared in situ by reaction of 2-propenylbenzaldehydes with 1,1-dimethylhydrazine, which exhibited superior performance when compared with other hydrazine derivatives Minor amounts of the related 3,4-dihydro isoquinolines II were formed concomitantly with the isoquinolines, and a mechanism for their generation was proposed. In general, the transformation proceeded in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Safety of 3-Hydroxy-5-methoxybenzaldehyde).
3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 3-Hydroxy-5-methoxybenzaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem