Juvenile hormone like substances. Part XIV. Synthesis and biological activities of some juvenile hormone analogues containing peptidic feature was written by Mahajan, R. K.;Sharma, G. C.. And the article was included in Journal of Indian Council of Chemists in 1998.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
Juvenile hormone analogs which contain glycinate moiety, i.e. 4-RC6H4OCH2CON(R1)CH2CO2R3 (R = H, Cl, Me, OMe, NO2, R1 = H, R3 = CHMe2; R = H, Cl, Me, OMe, R1 = H, R3 = CH2Me; R = H, Cl, Me, OMe, R1 = H, R3 = CH2CHMe2;R = H, Cl, R1 = Me, R3 = CH2Me), were synthesized. Preliminary biol. screening of PhOCH2CONHCH2CO2CHMe2 showed a pos. juvenile hormonal activity against potato tuber moth Phthorimaea operculella. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem