Rongalite-Mediated Transition Metal- and Hydride-Free Chemoselective Reduction of α-Keto Esters and α-Keto Amides was written by Golla, Sivaparwathi;Kokatla, Hari Prasad. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C8H10O2 This article mentions the following:
A transition metal- and hydride-free protocol was developed for the chemoselective reduction of α-keto esters and αketo amides using rongalite as a reducing agent. Here, rongalite acts as a hydride-free reducing agent via a radical mechanism. This protocol offered the synthesis of a wide range of α-hydroxy esters ArCHOHC(O)OR [Ar = Ph, 4-MeC6H4, 1-naphthyl, etc.; R = Et, i-Pr, Bn, etc.] and α-hydroxy amides ArCHOHC(O)NR1R2 [Ar = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; R1 = H, Me; R2 = Ph, 4-MeC6H4, Bn, etc.] with 85-98% yields. This chemoselective method was compatible with other reducible functionalities such as halides, alkenes, amides and nitriles. The use of inexpensive rongalite (ca. $0.03/1 g), mild reaction conditions, and gram-scale synthesis were some of the key features of this methodol. Also, cyclandelate, a vasodilator drug, was synthesized in gram scale with 79% yield. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Computed Properties of C8H10O2).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Computed Properties of C8H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem