Month: December 2022

Access to sultams by rhodium(III)-catalyzed directed C-H activation was written by Pham, Manh V.;Ye, Baihua;Cramer, Nicolai. And the article was included in Angewandte Chemie, International Edition in 2012.Application of 16356-02-8 This article mentions the following:

Acylated sulfonamides were established as suitable directing groups for rhodium(III)-catalyzed C-H bond activations. The cyclo-metalated intermediates readily react with a broad range of internal alkynes and open a rapid and general access to aryl sultams. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Application of 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application of 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin was written by Hidaka, Koushi;Kimura, Tooru;Ruben, Adam J.;Uemura, Tsuyoshi;Kamiya, Mami;Kiso, Aiko;Okamoto, Tetsuya;Tsuchiya, Yumi;Hayashi, Yoshio;Freire, Ernesto;Kiso, Yoshiaki. And the article was included in Bioorganic & Medicinal Chemistry in 2008.COA of Formula: C9H10O4 This article mentions the following:

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol was written by Samovich, Svetlana N.;Sladkova, Anastasia A.;Sverdlov, Roman L.;Edimecheva, Irina P.;Shadyro, Oleg I.. And the article was included in Chemistry and Physics of Lipids in 2019.COA of Formula: C9H10O4 This article mentions the following:

Effects of quinones and azoles on the formation of steady-state radiolysis products in aqueous solutions of glycerol-1-phosphate and aqueous dispersions of 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol has been investigated. The data obtained by LC-MS-ESI and spectrophotometric measurements shows that the compounds having quinoid structures, including the antitumor agent doxorubicin, and azoles having nitro groups effectively inhibit free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol, decreasing the radiation-chem. yields of either inorganic phosphate or phosphatidic acid resp. The observed effects of blocking free-radical processes are believed to be related to the ability of the tested compounds to oxidize α-hydroxyl-containing carbon-centered radicals of starting substrates, which give rise to fragmentation reaction. The possibility of using the discovered properties of quinones, doxorubicin and nitroazoles to provide practical solutions in oncol. radiotherapy and pathophysiol. is discussed. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7COA of Formula: C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products was written by Woo, Yin-Tak;Lai, David;McLain, Jennifer L.;Manibusan, Mary Ko;Dellarco, Vicki. And the article was included in Environmental Health Perspectives Supplements in 2002.Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

Disinfection byproducts (DBPs) are formed when disinfectants such as chlorine, chloramine, and ozone react with organic and inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over the possible adverse health effects of DBPs. To date, several hundred DBPs have been identified. To prioritize research efforts, an in-depth, mechanism-based structure-activity relationship anal., supplemented by extensive literature search for genotoxicity and other data, was conducted for ranking the carcinogenic potential of DBPs that met the following criteria: (a) detected in actual drinking water samples, (b) have insufficient cancer bioassay data for risk assessment, and (c) have structural features/alerts or short-term predictive assays indicative of carcinogenic potential. A semiquant. concern rating scale of low, marginal, low-moderate, moderate, high-moderate, and high was used along with delineation of scientific rationale. Of the 209 DBPs analyzed, 20 were of priority concern with a moderate or high-moderate rating. Of these, four were structural analogs of MX and five were haloalkanes that presumably will be controlled by existing and future THM regulations. The other eleven DBPs, which included halonitriles (6), haloketones (2), haloaldehyde (1), halonitroalkane (1), and dialdehyde (1), are suitable priority candidates for future carcinogenicity testing and/or mechanistic studies. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Engaging Ag(0) single atoms in silver(I) salts-mediated C-B and C-S coupling under visible light irradiation was written by Cui, Enxin;Qiao, Dan;Li, Haibin;Guo, Lirong;Tung, Chen-Ho;Wang, Yifeng. And the article was included in Journal of Catalysis in 2021.Related Products of 365564-07-4 This article mentions the following:

Silver(I) salts were found active in the borylation and sulfenylation of aryl iodides under visible light irradiation The optimized borylation protocol using AgF did not need any additive, operated under very mild conditions, and well tolerated a broad scope of substrates and boron sources. Formation of Ag(0) single atoms (AgSAs) during the borylation reactions was examined using high-angle annular dark field aberration-corrected scanning transmission electron microscope (HAADF AC-STEM) and ESR (EPR). The activities of the silver(I) salts were affected by the anions and could be associated with their abilities in formation of AgSAs during the reactions. Kinetic studies showed that the deiodination rate was linearly correlated with the loading of AgSAs, and hence AgSAs were the true catalytic centers for the 1e^–-reduction of the C-I moieties. The oxidation state of AgSAs kept 0 in both the resting and the working states. A “work-in-tandem” mechanism involving AgSAs as the catalytic centers and AgNPs as the light absorber to achieve the borylation of aryl iodides under visible light irradiation is proposed. The current approach not only provides an alternative system for borylation and sulfenylation of aryl iodides, but also reveals a new activity of silver(I) salts involving AgSAs under visible light irradiation In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Related Products of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetics and mechanism of oxidation of some meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione in non-aqueous medium was written by Palaniappan, An.;Srinivasan, S.;Senthilkumar, S.. And the article was included in Asian Journal of Chemistry in 2002.Formula: C9H10O4 This article mentions the following:

The kinetics of oxidation of a number of meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione (NCPD) were studied in methanol medium. The reaction shows unit order dependence with respect to oxidant and the order with respect to substrate varies depending on the nature of the substituent present in the ring. The rate is showing an inverse order of dependence with respect to [TsOH]. The rate increases with decrease in the percentage of methanol. Increase in ionic strength has no effect on the reaction rate. From the kinetic data obtained the activation parameters were computed and a suitable mechanism was proposed in accordance with multiparameter correlation anal. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Benzylpiperazine derivatives. VI. Design and syntheses of vinylogs of 1-benzyl-4-diphenylmethylpiperazine derivatives and their cerebral vasodilating activities was written by Ohtaka, Hiroshi;Kanazawa, Toshiro;Ito, Keizo;Tsukamoto, Goro. And the article was included in Chemical & Pharmaceutical Bulletin in 1987.HPLC of Formula: 6972-61-8 This article mentions the following:

Based on previous quant. structure-activity relationship (QSAR) results on cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazines, 1–cinnamyl-4-diphenylmethylpiperazines I (R = H, MeO; R¹ = H, F), having electron-donating groups on the cinnamyl moiety, were designed. Two methods of synthesis are reported. Thus, 2,3,4-(MeO)₃C₆H₂CH:CHCO₂H was treated sequentially with Et₃N, ClCO₂Et and then bis(fluorophenyl)methylpiperazine (II) in Me₃COH-MeCN to give the [bis(fluorophenyl)methyl](trimethoxycinnamoyl)piperazine III. Reducing III with NaAlH₂(OCH₂CH₂OMe)₂ gave 56% I (R = MeO, R¹ = F). As expected from the QSAR results, these compounds exhibited stronger potency and longer-lasting effects than cinnarizine and flunarizine. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A highly efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was written by Li, Dengke;Xu, Ning;Zhang, Yicheng;Wang, Lei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Electric Literature of C12H17NO2 This article mentions the following:

An efficient palladium-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was developed. A variety of anilide derivatives reacted with aryl acyl peroxides to afford the corresponding ortho-arylation products. N-methoxyarylamide reactants led to the formation of phenanthridinone derivatives (i.e., cyclic Weinreb N-(alkoxy)alkanamide analogs). Under optimized conditions the synthesis of the target compounds was achieved using palladium(II) acetate as a catalyst. Starting materials included N-(phenyl)propanamide derivatives, bis(benzoyl)peroxide, N-(methoxy)benzamide derivatives The title compounds thus formed included biaryl-amide derivatives, such as N-[1,1′-biphenyl]-2-yl-2,2-dimethylpropanamide, 1-[[1,1′-biphenyl]-2-yl]-2-pyrrolidinone (cyclic amide analog), and 5-methoxy-6(5H)-phenanthridinone derivatives (Weinreb amide analogs). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Electric Literature of C12H17NO2).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Electric Literature of C12H17NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nickel-catalyzed (E)-selective semihydrogenation of internal alkynes with hypophosphorous acid was written by Chen, Tieqiao;Xiao, Jing;Zhou, Yongbo;Yin, Shuangfeng;Han, Li-Biao. And the article was included in Journal of Organometallic Chemistry in 2014.Application of 39969-26-1 This article mentions the following:

A facile Ni-catalyzed semihydrogenation of internal alkynes to (E)-alkenes using the cheap and easily handled hypophosphorous acid as a hydrogen donor was described. This reaction is featured by high reaction efficiency to produce the corresponding (E)-alkenes selectively. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Application of 39969-26-1).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 39969-26-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A short efficient synthesis of 4-amino-2,3-dihydrobenzofuran was written by Marburg, S.;Tolman, R. L.. And the article was included in Journal of Heterocyclic Chemistry in 1980.Recommanded Product: 56619-93-3 This article mentions the following:

3-MeOC₆H₄NHCOCMe₃ was treated with BuLi and ethylene oxide and the 2-(hydroxyethyl) derivative cyclized by HBr to give the title compound (I; R = NH₂, R¹ = H), which underwent chlorination to give I (R = NH₂, R¹ = Cl). Sandmeyer reaction of I (R = NH₂, R¹ = H) gave I (R = CN, R¹ = H). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem