Month: December 2022

Rhodium(III)-Catalyzed Directed C-H Dienylation of Anilides with Allenes Leads to Highly Conjugated Systems was written by Ghosh, Chiranjit;Nagtilak, Prajyot Jayadev;Kapur, Manmohan. And the article was included in Organic Letters in 2019.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

Allenes are unique coupling partners in transition-metal-catalyzed C-H functionalization leading to a variety of products via alkenylation, allenylation, allylation, and annulation reactions. The outcome is governed by both the reactivity of the allene and the formation and stability of the organometallic intermediate. An efficient Rh(III)-catalyzed, weakly coordinating group-directed dienylation of electronically unbiased allenes is developed using an N-acyl amino acid as a ligand. Further elaboration of the dienylated products to construct polycyclic compounds is also described. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Safety of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Glyme-lithium bis(trifluoromethylsulfonyl)amide superconcentrated electrolytes: salt addition to solvate ionic liquids lowers ionicity but liberates lithium ions was written by Kitada, Atsushi;Koujin, Yoshiki;Shimizu, Masahiro;Kawata, Kio;Yoshinaka, Chiaki;Saimura, Masayuki;Nagata, Takashi;Katahira, Masato;Fukami, Kazuhiro;Murase, Kuniaki. And the article was included in Journal of the Electrochemical Society in 2021.Quality Control of 2,5,8,11-Tetraoxadodecane This article mentions the following:

Solvate ionic liquids (ILs) such as binary equimolar mixtures of glymes (ethyleneglycol-dimethylether or CH₃(OCH₂CH₂)_nOCH₃) and lithium bis(trifluoromethylsulfonyl)amide (LiTf₂N; Tf = SO₂CF₃) are known to show identical self-diffusion coefficients for glymes and Li+ ions. Here, we report that the addition of LiTf₂N to the solvate ILs drastically changes their electrolyte properties. When the lithium salts are added to give the super-concentrated electrolytes with [O]/[Li⁺] = 3 (molar ratio of ether oxygen to Li⁺), ligand exchange or hopping conduction of Li⁺ takes place for triglyme (G3; n = 3) and tetraglyme (G4; n = 4). In addition, the Li⁺ transference number t_Li⁺(EC), electrochem. measured under anion blocking conditions, increases about 3-6 times compared with the solvate ILs. Consequently, segmental motion of glymes apparently affects the transport properties even for the shorter G3 in the super-concentrated region. The relationship between the coordination structure and the transport properties are also discussed as a function of ionicity, the extent of the contribution of self-diffusion to the actual ion conduction. Plots vs ionicity demonstrate that a clear line can be drawn between the solvate ILs and the super-concentrated electrolytes. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Quality Control of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Quality Control of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans was written by Sivaraman, Aneesh;Harmalkar, Dipesh S.;Kang, Jiyoon;Choi, Yongseok;Lee, Kyeong. And the article was included in Organic & Biomolecular Chemistry in 2019.HPLC of Formula: 365564-07-4 This article mentions the following:

The first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans was reported. The present protocol provided shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4HPLC of Formula: 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Modeling Phase Equilibria of Ethers and Alcohols with GCA-EOS for Assessing the Coblending of Advanced Biofuels was written by Prieto, Mariana Gonzalez;Sanchez, Francisco A.;Pereda, Selva. And the article was included in Journal of Chemical & Engineering Data in 2019.Quality Control of 2,5,8,11-Tetraoxadodecane This article mentions the following:

In this work, we extend the Group Contribution with Association Equation of State (GCA-EOS) to model the phase behavior of mixtures comprising ethers and alcs. The model parametrization was done using few binary vapor-liquid equilibrium data sets of linear monoethers. We also model the behavior of branched ethers, traditionally used as fuel additives, as well as that of polyethers, which are nowadays being proposed as potential biofuels. Therefore, we investigate, not only the phase equilibrium, but also excess enthalpies of these three types of ethers in mixtures with alcs. Finally, we show that the GCA-EOS is able to predict the phase behavior of polyethers, as well as that of branched ethers, using a group contribution approach. This work is part of a broader project for the development of a robust and predictive thermodn. model for process and product design in the context of biomass valorization. In addition, the parametrization reported here aims to provide a reliable framework specific for the description of thermodn. properties of biofuel blends. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Quality Control of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Radical Addition of 4-Hydroxyquinazolines and Alkylation of Quinones by the Electro-Induced Homolysis of 4-Alkyl-1,4-dihydropyridines was written by Luo, Xiaosheng;Feng, Qiping;Wang, Ping. And the article was included in Synthesis in 2022.Electric Literature of C9H10O4 This article mentions the following:

The formation of C(sp³)-centered radicals via the electro-induced homolysis of 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) is reported. The resulting alkyl radicals reacted with 4-hydroxyquinazolines or quinones to afford 2-alkyldihydroquinazolinones or alkylated quinones. A broad range of alkyl DHPs could be used as versatile radical precursors under electrolysis conditions. This alterative strategy provided a simple and effective pathway for the construction of C(sp²)-C(sp³) and C(sp³)-C(sp³) bonds under mild conditions. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Electric Literature of C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recyclization to 1-pyrazol-3-yl-1H-benzimidazoles in the reaction of 2-phenacyl-1H-benzimidazole hydrazone with carboxylic acids was written by Dzvinchuk, I. B.;Vypirailenko, A. V.;Lozinskii, M. O.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1999.Synthetic Route of C9H10O4 This article mentions the following:

Reaction of 2-phenacyl-1H-benzimidazole hydrazone (I) with RCOOH (R = H, Me, PhCH₂, 2-thienylmethyl, aryloxymethyl) at 150-200° gave 1-pyrazol-3-yl-1H-benzimidazoles (II). In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Synthetic Route of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Synthetic Route of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Silica gel-assisted reductive cyclization of 2-nitro-β-piperidinostyrenes, derived from 2-nitrotoluenes, to indoles was written by Kawase, Masami;Sinhababu, Achintya K.;Borchardt, Ronald T.. And the article was included in Journal of Heterocyclic Chemistry in 1987.Electric Literature of C8H9NO3 This article mentions the following:

Condensation reaction of nitrotoluenes I (R = H, F, OMe, OCH₂Ph; R¹ = H, MeO, PhCH₂O; R² = H, Cl, PhCH₂O) with tripiperidinomethane, followed by reductive intramol. cyclocondensation of the product nitropiperidinostyrenes II with Fe-silica gel gave 62-94% indoles III. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Electric Literature of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Arabinogalactan propargyl ethers: Au-catalysed hydroamination by imidazols was written by Grishchenko, Lyudmila A.;Parshina, Lidiya N.;Larina, Lyudmila I.;Belovezhets, Lyudmila A.;Klimenkov, Igor V.;Ustinov, Alexander Yu.;Trofimov, Boris A.. And the article was included in Carbohydrate Polymers in 2020.HPLC of Formula: 111-77-3 This article mentions the following:

A method for synthesis of pharmacol. prospective arabinogalactan (AG) imidazole- and benzimidazole derivatives in a yield of up to 97% via Au(III)-catalyzed hydroamination of AG propargyl ethers has been developed. It is found that in the presence of 5 mol% HAuC1₄ and 10-fold excess imidazole relative to the propargyl groups, the hydroamination successfully competes with crosslinking processes to afford products soluble in DMSO and aqueous HCl solutions (degree of substitution of imidazolylpropenyl fragments 0.5-1.8, yield 62-97%). It is established that under the conditions of hydroamination Au(III) is reduced to give mainly Au(0) and minor amounts of Au(I), which are contained in AG imidazole derivatives as particles of 190-640 nm in size. Hydrochlorides of Au-containing AG imidazole derivatives show high bacteriostatic activity with respect to test gram-pos. microorganisms and thus confirming their prospects as new AG-derived bioactive agents. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3HPLC of Formula: 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells was written by Germain, Andrew R.;Carmody, Leigh C.;Nag, Partha P.;Morgan, Barbara;VerPlank, Lynn;Fernandez, Cristina;Donckele, Etienne;Feng, Yuxiong;Perez, Jose R.;Dandapani, Sivaraman;Palmer, Michelle;Lander, Eric S.;Gupta, Piyush B.;Schreiber, Stuart L.;Munoz, Benito. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Synthetic Route of C11H12O4 This article mentions the following:

A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Mol. Libraries Small Mol. Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Synthetic Route of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Synthetic Route of C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium-catalyzed amination in the synthesis of aza- and diazacrown trismacrocyclic compounds was written by Yakushev, A. A.;Anokhin, M. V.;Averin, A. D.;Maloshitskaya, O. A.;Beletskaya, I. P.. And the article was included in Russian Chemical Bulletin in 2012.Product Details of 66943-05-3 This article mentions the following:

Palladium-catalyzed C-N-cross-coupling of N,N’-bis(bromobenzyl) diazacrown compounds with two equivalent of 1-aza-15-crown-5 and 1-aza-18-crown-6 ethers furnished trismacrocyclic compounds with isolated macrocycles. Macrotricyclic cryptands were obtained when diazacrown ethers were used as N-components. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Product Details of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Product Details of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem