Month: December 2022

Washington, Jack B. published the artcileTrialkylammonium salt degradation: implications for methylation and cross-coupling, Name: 2-Methoxynaphthalene, the publication is Chemical Science (2021), 12(20), 6949-6963, database is CAplus and MEDLINE.

This study presented a mechanistic degradation anal. of N,N,N-trimethylanilinium salts and highlighted implications for synthetic applications of this important class of salts. Kinetic degradation studies, in both solid and solution phases, had delivered insights into phys. and chem. parameters affecting anilinium salt stability. ¹H NMR kinetic anal. of salt degradation had evidenced thermal degradation to Me iodide and parent aniline, consistent with a closed-shell S_N2-centered degradative pathway, and Me iodide being key reactive species in applied methylation procedures. Furthermore, effect of halide and non-nucleophilic counterions on salt degradation had been investigated, along with deuterium isotope and solvent effects. New mechanistic insights had enabled investigation of use of trimethylanilinium salts in O-methylation and in improved cross-coupling strategies. Finally, detailed computational studies had helped highlight limitations in current state-of-the-art of solvation modeling of reaction in which bulk medium undergoes exptl. observable changes over reaction timecourse.

Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C14H10O4, Name: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Rozas, Robinson published the artcileSolvent effects on the molecular structure of isolated lignins of Eucalyptus nitens wood and oxidative depolymerization to phenolic chemicals, Synthetic Route of 134-96-3, the publication is Polymer Degradation and Stability (2022), 109973, database is CAplus.

The aim of the present work was to study the effect of a solvent/water mixture on the structural characteristics of extracted lignin from Eucalyptus nitens, and to relate the functional groups and inter unit linkages present in the lignin with the distribution of phenolic compounds obtained after its alk. oxidation The high content of β-O-4′ substructures linked to a S unit in organosolv lignins of E. nitens lignin could be linked to the high yield of syringaldehyde in its alk. oxidation Kraft lignin oxidation gives rise to lower content of syringaldehyde when compared with organosolv lignins. This might be due to the higher proportion of condensed structures, mainly β-β’ (∼42%) and spirodienone (∼14%). Fukui functions showed that the regions with higher probability for an electrophilic attack on lignin would be located on Ph rings and on the phenolic -OH group (benzylic position), whereas nucleophilic attacks in some cases were located over the double bond and ring. This work contributed to a better description of the proposed oxidative depolymerization mechanisms.

Polymer Degradation and Stability published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Shankar, Jaya Seeli published the artcileStudies on Optical Characteristics of Multicolor Emitting MEH-PPV/ZnO Hybrid Nanocomposite, Formula: C15H24O2, the publication is Polymer-Plastics Technology and Materials (2019), 58(2), 148-157, database is CAplus.

The present work endeavors towards the scientific study on influence of ZnO nanoparticles on the optical characteristics of Poly [2 Methoxy (5, 2′ Ethylhexyloxy)-P-Phenylenevinylene] (MEH-PPV), a light emitting polymer. Hybrid nanocomposites of MEH-PPV were prepared by dispersing ZnO nanorods at loading concentrations of 1 weight % and 3 weight %. The structural characteristics of the hybrid composites were investigated using FTIR spectroscopy and X-ray diffraction. The UV absorption spectra and Photoluminescence emission spectra were analyzed in order to study the optical characteristics of nanocomposite. The optical constants were determined and the suitability of the composites for light emission was analyzed. The incorporation of ZnO nanorods facilitates the shift in emission wavelength and witnesses the color tuning ability and multicolor emission from the composite.

Polymer-Plastics Technology and Materials published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C4H3ClN2O, Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Makkad, Sarabjot Kaur published the artcileπ-Conjugated Chromophore Incorporated Polystyrene Nanobeads as Single Optical Agent for Three-Channel Fluorescent Probe in Bioimaging Application, Synthetic Route of 146370-51-6, the publication is ACS Biomaterials Science & Engineering (2017), 3(8), 1788-1798, database is CAplus and MEDLINE.

Fluorescent polystyrene (PS) nanobeads in the size range ∼70-120 nm incorporating perylene bisimide (PBI-PS) and/or oligo(p-phenylenevinylene) (OPV-PS) were developed by the miniemulsion polymerization technique. A dye loading content (DLC) of <3% was sufficient to impart high fluorescence emission capability to the PS beads. OPV-PS exhibited emission in the range 400-550 nm with peak emission at 450 nm (λ_ex = 350 nm; φ_FL = 26%); PBI-PS showed emission from 520-650 nm with peak emission at 545 nm (λ_ex = 490 nm; φ_FL = 9.7%) in 1× PBS buffer, whereas OPV(PBI)-PS nanobeads incorporating both the fluorophores exhibited multicolor emission capabilities (λ_ex from 350 to 490 nm). The nanoparticles were characterized by field-emission SEM (FESEM), TEM and dynamic light scattering (DLS) for size and zeta potential for surface charge. For bioimaging applications, the PS nanoparticles were incubated with HeLa cells. Cell viability anal. involving HeLa cells showed >90% cell viability confirming the biocompatibility of the PS beads. The cellular uptake of the nanoparticles was confirmed by flow cytometry anal. and confocal laser scanning microscopy (CLSM) images. The subcellular localization of the nanoparticles in the cytoplasm could be precisely established by their simultaneous multicolor emission. The PS-based single optical agent presented here that can function as three-channel fluorescent probe to meet the requirements for multicolor bioimaging is advantageous.

ACS Biomaterials Science & Engineering published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Synthetic Route of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ogawa, Anthony K. published the artcileTotal Synthesis of Calyculin C, Application of (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the American Chemical Society (1998), 120(48), 12435-12442, database is CAplus.

The study of phosphatases continues to flourish given their prominence in signal transduction pathways and the regulation of cell function. Our research efforts in this area focus on the potent inhibition of serine/threonine phosphatases, PP1 and PP2A, by a structurally diverse class of natural products. We herein report the completed total synthesis of the serine/threonine phosphatase inhibitor calyculin C as part of an ongoing effort to elucidate key structural requirements for phosphatase inhibition by the aforementioned diverse class of natural products. Synthetic issues addressed include (1) the remote protecting group effect on Brown crotylboration diastereoselectivity during the introduction of the C₁₀-C₁₁ stereocenters and (2) the formation of the C₂₅-C₂₆ double bond using a fully deprotected C₂₆-C₃₇ phosphonium salt.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Application of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dinh, Tam Q. published the artcileA Convergent Total Synthesis of the Multidrug Resistance-Reversing Agent Hapalosin, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of Organic Chemistry (1995), 60(25), 8118-19, database is CAplus.

The novel cyclic depsipeptide hapalosin (I) was recently isolated and has shown great potential for reversing multidrug resistance in vitro. The first total synthesis of hapalosin has been achieved in 18 steps. Two diastereoselective Brown allylborations established the absolute stereochem. of 3 of the 5 stereocenters in hapalosin. After convergence of two fragments, the pentultimate step was a macrolactonization under modified Mukaiyama conditions.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pottel, Joshua published the artcileThe activities of drug inactive ingredients on biological targets, Related Products of ethers-buliding-blocks, the publication is Science (Washington, DC, United States) (2020), 369(6502), 403-413, database is CAplus and MEDLINE.

Excipients, considered “inactive ingredients,” are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We computed the likelihood that approved excipients would bind to mol. targets. Testing in vitro revealed 25 excipient activities, ranging from low-nanomolar to high-micromolar concentration Another 109 activities were identified by testing against clin. safety targets. In cellular models, five excipients had fingerprints predictive of system-level toxicity. Exposures of seven excipients were investigated, and in certain populations, two of these may reach levels of in vitro target potency, including brain and gut exposure of thimerosal and its major metabolite, which had dopamine D3 receptor dissociation constant K_d values of 320 and 210 nM, resp. Although most excipients deserve their status as inert, many approved excipients may directly modulate physiol. relevant targets.

Science (Washington, DC, United States) published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chiellini, Grazia published the artcileA high-affinity subtype-selective agonist ligand for the thyroid hormone receptor, Recommanded Product: 2-Isopropylanisole, the publication is Chemistry & Biology (1998), 5(6), 299-306, database is CAplus and MEDLINE.

Thyroid hormones regulate many different physiol. processes in different tissues in vertebrates. Most of the actions of thyroid hormones are mediated by the thyroid hormone receptor (TR), which is a member of the nuclear receptor superfamily of ligand-activated transcription regulators. There are two different genes that encode two different TRs, TRα and TRβ, and these two TRs are often co-expressed at different levels in different tissues. Most thyroid hormones do not discriminate between the two TRs and bind both with similar affinities. The authors have designed and synthesized a thyroid hormone analog that has high affinity for the TRs and is selective in both binding and activation functions for TRβ over TRα. The compound, GC-1, was initially designed to solve synthetic problems that limit thyroid hormone analog preparation, and contains several structural changes with respect to the natural hormone 3,5,3′-triiodo-L-thyronine (T₃). These changes include replacement of the three iodines with Me and iso-Pr groups, replacement of the biaryl ether linkage with a methylene linkage, and replacement of the amino-acid sidechain with an oxyacetic-acid sidechain. The result of this study show that GC-1 is a member of a new class of thyromimetic compounds that are more synthetically accessible than traditional thyromimetics and have potentially useful receptor binding and activation properties. The TRβ selectivity of GC-1 is particularly interesting and suggests that GC-1 might be a useful in vivo probe for studying the physiol. roles of the different thyroid hormone receptor isoforms.

Chemistry & Biology published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kaminker, Revital published the artcileTuning of protease resistance in oligopeptides through N-alkylation, Product Details of C25H23NO4, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(69), 9631-9634, database is CAplus and MEDLINE.

N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-Me have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides.

Chemical Communications (Cambridge, United Kingdom) published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Product Details of C25H23NO4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Horton, Martin N. published the artcileSynthesis of [D5-ethyl]-tamoxifen; a mechanistic probe of tamoxifen induced hepatic DNA adduct formation, Related Products of ethers-buliding-blocks, the main research area is tamoxifen deuterated.

Tamoxifen which incorporates a fully deuterated Et group, [D5-ethyl]-tamoxifen, has been synthesized in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation. The pentadeuteroethyl group was introduced into the tamoxifen structure by treatment of the ketone precursor 1-[4-(2-chloroethoxy)phenyl]-2-phenylethanone, as its sodium enolate, with [D5]-iodoethane.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about tamoxifen deuterated. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem