Month: December 2022

Huang, Lin published the artcileRuthenium-Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism, Safety of 2-Methoxynaphthalene, the publication is Angewandte Chemie, International Edition (2021), 60(13), 7290-7296, database is CAplus and MEDLINE.

The direct dehydrogenation of alkanes is among the most efficient ways to access valuable alkene products. Although several catalysts have been designed to promote this transformation, they have unfortunately found limited applications in fine chem. synthesis. Here, we report a conceptually novel strategy for the catalytic, intermol. dehydrogenation of alkanes using a ruthenium catalyst. The combination of a redox-active ligand and a sterically hindered aryl radical intermediate has unleashed this novel strategy. Importantly, mechanistic investigations have been performed to provide a conceptual framework for the further development of this new catalytic dehydrogenation system.

Angewandte Chemie, International Edition published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Manley, Peter J. published the artcileA new synthesis of naphthyridinones and quinolinones: palladium-catalyzed amidation of o-carbonyl-substituted aryl halides, HPLC of Formula: 16332-06-2, the publication is Organic Letters (2004), 6(14), 2433-2435, database is CAplus and MEDLINE.

An alternative to the Friedlaender condensation for the synthesis of naphthyridinones, e.g., I, and quinolinones has been discovered. Palladium-catalyzed amidation of halo aromatics substituted in the ortho position by a carbonyl functional group or its equivalent with primary or secondary amides leads to the formation of substituted naphthyridinones and quinolinones.

Organic Letters published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, HPLC of Formula: 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Baciocchi, Enrico published the artcileOxidation of non-phenolic β-O-aryl-lignin model dimers catalyzed by lignin peroxidase. Comparison with the oxidation induced by potassium 12-tungstocobalt(III)ate, HPLC of Formula: 183303-74-4, the publication is Journal of the Chemical Society, Perkin Transactions 2 (2001), 1506-1511, database is CAplus.

The H₂O₂-promoted oxidations of the non-phenolic β-O-aryl-lignin model dimers 1-(3,4-dimethoxyphenyl)-2-phenoxyethanol (I) and 2-(4-methoxyphenoxy)-1-phenylethanol (II) catalyzed by lignin peroxidase (III) at pH =4.0 were studied. The oxidation of I mainly leads to the corresponding ketone, indicating that the prevailing reaction of the intermediate radical cation I^+· is Cα-H deprotonation. The oxidation of II forms 2-(4-methoxyphenoxy)-2-phenylethanol, an isomer of II, 2-phenyl-1,4-dioxaspiro[4,5]deca-6,9-dien-8-one (IV), and products coming from the cleavage of the C-C bond γ to the more electron rich ring. The formation of all of these products can be rationalized by assuming that the main reaction of the intermediate II^+· is a nucleophilic attack of the alc. OH group on the ring bearing the pos. charge. This leads to a spirocyclohexadienyl radical, which either is then oxidized to the dioxaspirodecadienone IV or undergoes ring opening to give an alkoxyl radical from which the isomer of II and the C-C bond cleavage products may form. Support for this mechanism was provided by a study of the oxidation of 4-MeOC₆H₄OCH₂CD₂OH and by comparing the results with those obtained when the alkoxyl radical 4-MeOC₆H₄OCH₂CD₂O^· was generated from 4-MeOC₆H₄OCH₂CD₂OOt-Bu. The oxidation of I induced by the genuine one-electron oxidant K 12-tungstocobalt(III)ate (V) at pH =4.0 confirms the results obtained with III. However, under the same conditions, no fragmentation products were observed in the oxidation of II, probably because of a fast oxidation, by V, of the spirocyclohexadienyl radical.

Journal of the Chemical Society, Perkin Transactions 2 published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, HPLC of Formula: 183303-74-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fioravanti, Rossella published the artcileSynthesis and microbiological evaluations of (N-heteroaryl)arylmethanamines and their Schiff bases, HPLC of Formula: 52818-63-0, the publication is Farmaco (1996), 51(10), 643-652, database is CAplus.

The synthesis as well as the antimicrobial and antiviral activities of new (N-heteroaryl)arylmethanamines and their Schiff bases are reported. None of the tested compounds shown activity against Herpes simplex virus type 2 and against Gram-pos. and Gram-neg. bacteria. Weak or moderate activity on poliovirus Sabin type 1, on reverse transcriptase, and against Cryptococcus neoformans was shown by some of the tested compounds Several synthesized compounds exhibited a moderate or good activity against strains of Candida albicans, whereas only some of the tested compounds were found moderately active against strains of Candida sp. Instead numerous new compounds I or II were active against isolates of plant pathogenic fungi. The obtained results are discussed on the basis of structure-activity relationships.

Farmaco published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kori, Santosh published the artcileRoom temperature HFIP/Ag-promoted palladium-catalyzed C-H functionalization of benzothiazole with iodoarenes, Product Details of C8H10O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(6), 847-850, database is CAplus and MEDLINE.

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazoles I (R = H, Me, Cl, F) with a wide variety of iodoarenes R¹I (R¹ = C₆H₅, 4-ClC₆H₄, 2-naphthyl, etc.) under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazoles I has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents II, PMX-610 and CJM-126 (precursor).

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ghosal, Manuka published the artcileTotal synthesis of (±)-shonanyl methyl ether and (±)-ferruginyl methyl ether, Related Products of ethers-buliding-blocks, the publication is Tetrahedron Letters (1989), 30(26), 3469-70, database is CAplus.

An efficient reductive methylation of the tricyclic ketone I in anhydrous NH₃ provided the β,γ-unsaturated ketone II in high yield which was subsequently converted into (±)-shonanyl Me ether (III) and (±)-ferruginyl Me ether (IV).

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhattacharyya, A. C. published the artcileGas chromatography of monohydric phenols via O-methylation, Related Products of ethers-buliding-blocks, the publication is Analytical Chemistry (1968), 40(12), 1873-6, database is CAplus.

Monohydric phenols were determined by gas chromatog., after conventional O-methylation, on an 8% Apiezon L/celite column at 140° or a 10% Apiezon L/celite column at 180°. N carrier gas and a flame ionization detector were used. The aryl Me ether was chromatographed as a 0.2-μl. aliquot of a concentrated Et2O solution The procedure gave quant. etherification of 34 phenols. A 8-component synthetic mixture of phenols was analyzed, using the column at 140° [component, weight % present (as phenol), weight % found (as phenol), given]: 3-methylanisole, 13.87, 13.39; 2,6-dimethylanisole, 6.53, 7.38; 2,5-dimethylanisole, 11.84, 11.80; 3,5-dimethylanisole, 23.70, 23.60; 2,4,6-trimethylanisole, 8.62, 9.58; 2-methyl-4-ethylanisole, 9.63, 8.36; 4-tert-butylanisole and 2,3,5-trimethylanisole, 22.07, 22.35; 2,3,4-trimethylanisole, 3.74, 3.54. The anal. was applied to distillates of tar acids obtained from hydrogenation experiments of Assam coal and from a com. high-temperature carbonization plant.

Analytical Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brown, Herbert C. published the artcileEnantiomeric Z- and E-crotyldiisopinocampheylboranes. Synthesis in high optical purity of all four possible stereoisomers of β-methylhomoallyl alcohols, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the American Chemical Society (1986), 108(2), 293-4, database is CAplus.

Enantiomerically pure Z-crotyldiisopinocampheylboranes are prepared from B-methoxydiisopinocampheylboranes and the allylic organopotassium compound from cis-2-butene. These enantiomeric Z-crotylboranes add to AcH regioselectively and stereoselectively to give erythro-(+)- and -(-)-3-methyl-4-penten-2-ols in ≥99% diastereoselectivities and ≥95% enantioselectivities. Similarly, enantiomeric E-crotyldiisopinocampheylboranes are prepared and add to AcH to give threo-(+)- and -(-)-3-methyl-4-penten-2-ols in ≥99% diastereoselectivities and ≥95% enantioselectivities.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brown, Herbert C. published the artcileChiral synthesis via organoboranes. 7. Diastereoselective and enantioselective synthesis of erythro- and threo-β-methylhomoallyl alcohols via enantiomeric (Z)- and (E)-crotylboranes, Name: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the American Chemical Society (1986), 108(19), 5919-23, database is CAplus and MEDLINE.

Isomerically pure (Z)- and (E)-crotylpotassiums were prepared by metalation of (Z)- and (E)-2-butene using a modified Schlosser procedure. The enantiomerically pure (Z)-crotyldiisopinocampheylboranes I and II were prepared by employing methoxydiisopinocampheylboranes, prepared from either (+)- or (-)-α-pinene, resp., and (Z)-crotylpotassium I and II retain their stereochem. identity under the reaction conditions and were condensed with RCHO (R = Me, Et, H₂C:CH, Ph) regioselectively and stereoselectively to yield the corresponding erythro-β-methylhomoallyl alcs. e.g., III, in ≥99% diastereoselectivities and ≥95% enantioselectivities. Similarly, the enantiomeric (E)-crotyldiisopinocampheylboranes were prepared and add to RCHO to yield the corresponding threo-β-methylhomoallyl alcs. with similar selectivities. Further, (Z)- and (E)-crotyldiisocaranylboranes IV were prepared and condensed with EtCHO to furnish the erythro– and threo-β-methylhomoallyl alcs., resp., in ≥99% diastereoselectivities and improved enantioselectivities (97%).

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Name: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lopez-Arencibia, Atteneri published the artcileNew phenalenone analogues with improved activity against Leishmania species, Product Details of C11H10O, the publication is Biomedicine & Pharmacotherapy (2020), 110814, database is CAplus and MEDLINE.

The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis parasites. In this research, we focused on the determination of the programmed cell death evidence by detecting the characteristic features of the apoptosis-like process, such as phosphatidylserine exposure and mitochondrial membrane potential, among others. The results showed that the new derivatives have comparable or better activity and selectivity than the commonly prescribed anti-leishmanial drug. This result was obtained by inducing stronger mitochondrial depolarization or more intense phosphatidylserine exposure than miltefosine, highlighting compound 8 with moreover 9-times better selectivity index. In addition, the new five mols. activated the apoptosis-like process in the parasite. All the signals observed were indicative of the death process that the parasites were undergoing.

Biomedicine & Pharmacotherapy published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Product Details of C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem