Month: December 2022

Das, Rima published the artcileI₂-TEMPO as an efficient oxidizing agent for the one-pot conversion of alcohol to amide using FeCl₃ as the catalyst, Related Products of ethers-buliding-blocks, the publication is Catalysis Communications (2012), 48-53, database is CAplus.

A high yield one-pot method for the synthesis of amides from alcs. is described. The aldehyde was generated in situ using iodine-TEMPO as oxidizing agent followed by intermediate oxime formation through reaction with NH₂OH·HCl and finally rearrangement of oxime catalyzed by FeCl₃.

Catalysis Communications published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jimenez-Sanchez, Maria published the artcileThe impact of ultrasound, micro-oxygenation and oak wood type on the phenolic and volatile composition of a Tempranillo red wine, Computed Properties of 134-96-3, the publication is LWT–Food Science and Technology (2022), 113618, database is CAplus.

The accelerated ageing of a Tempranillo red wine has been studied at pilot scale through the combined application of ultrasound, micro-oxygenation and different oak wood type chips (American, French and Spanish). The phenolic and volatile content of the aged samples and their sensory profiles have been determined The wine samples that had been aged using micro-oxygenation, French or American oak chips, and ultrasound revealed to be similar in terms of polyphenols to those wines that had been aged without implementing this last accelerating technique. Ageing time, with a high extraction kinetics, was the most significant variable with regard to their polyphenol content. In terms of volatiles, Spanish and French oak wood wine samples showed a similar behavior closely associated to ageing time, while American oak wood achieved a rather low enrichment in volatile constituents, resulting in a poor sensory profile of the final wines, which was particularly poor in the case of ultrasound aged wines.

LWT–Food Science and Technology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Computed Properties of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Felipe, Josyelen L. published the artcileAnti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids, Category: ethers-buliding-blocks, the publication is Bioorganic Chemistry (2022), 105485, database is CAplus and MEDLINE.

This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of their biol. activity. Analogs 8-13 (L13-L18) exhibited anti-inflammatory activity, inhibited glycoprotein expression (P-selectin) related to platelet activation, and were considered non- ulcerogenic in the animal model, even with the administration of 10 times higher than the dose used in reference therapy. In silico drug-likeness showed that the analogs are compliant with Lipinskis rule of five. A mol. docking study showed that the hybrids 8-13 (L13-L18) fitted similarly with celecoxib in the COX-2 active site. According to this data, it is possible to infer that extra hydrophobic interactions and the hydrogen interactions with the triazole core may improve the selectivity towards the COX-2 active site. Furthermore, the mol. docking study with P-selectin showed the binding affinity of the analogs in the active site, performing important interactions with amino acid residues such as Tyr 48. Whereas the P-selectin is a promising target to the design of new anti-inflammatory drugs with antithrombotic properties, a distinct butterfly-like structure of 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids synthesized in this work may be a safer alternative to the traditional COX-2 inhibitors.

Bioorganic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Monopoli, Antonio published the artcileA new expeditious synthesis of the core scaffold of salvianolic acid F trough a one-pot sequential Heck coupling catalyzed by palladium nanoparticles in ionic liquids, SDS of cas: 91-16-7, the publication is Journal of Organometallic Chemistry (2022), 122193, database is CAplus.

A new expeditious synthesis of tetra-Me salvianolic acid F (I) is presented. Starting from the naturally occurring veratrole, the target mol. is easily obtained in a one-pot mode via a sequential double Heck coupling catalyzed by palladium nanoparticles dispersed in ionic liquids The present method involves the chemoselective displacement of two different halogen atoms present on the veratrole ring and limits the need for tedious exptl. procedures. A 66% of overall yield can be achieved, that represents, as far as we know, one of the best results present in the literature, until now. This protocol can also open the way for the synthesis of unnatural salvianolic-like compounds with potential bioactivity.

Journal of Organometallic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burnell, Robert H. published the artcileSynthesis of aromatic diterpenes. Synthesis of 12-hydroxyabieta-8,11,13-triene-3,7-dione, Recommanded Product: 2-Isopropylanisole, the publication is Synthetic Communications (1991), 21(1), 127-32, database is CAplus.

Model studies involving cationic cyclization. of suitable dienes have provided a synthesis of the title compound (I). Preparation of the dienes from available aromatic starting materials and the modification of the cyclized products are described. Thus, nitrile II in MeNO₂ was treated with PhSMe and BF₃ to give III, which was converted to I in 4 steps.

Synthetic Communications published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burnell, Robert H. published the artcileApproach to the synthesis of candelabrone and synthesis of 3,7-diketo-12-hydroxyabieta-8,11,13-triene., Product Details of C10H14O, the publication is Canadian Journal of Chemistry (1992), 70(5), 1446-54, database is CAplus.

An approach to the synthesis of aromatic diterpenes was tested for its generality. Phenylacetonitriles with increasing substitution on the aromatic ring were prepared and alkylated with geranyl bromide and the resulting dienes, e.g. I, subjected to cationic cyclization. The less-substituted examples afforded tricyclic products of the required stereochem., e.g. II, while the more highly substituted compounds cyclized with reduced yields or not at all. One of the intermediates III was used to synthesize nimosone IV, a natural diterpene isolated originally from Chamaecyparis formosensis and recently from Azadirachta indica.

Canadian Journal of Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ruan, Jing-Ya published the artcileStructural characterization of phenolic constituents from the rhizome of Imperata cylindrica var. major and their anti-inflammatory activity, HPLC of Formula: 134-96-3, the publication is Phytochemistry (Elsevier) (2022), 113076, database is CAplus and MEDLINE.

As one of raw materials, the rhizome of Imperata cylindrica var. major (Nees) C. E. Hubb. is used in kinds of preparations curing inflammation related diseases, while its effective substances are not yet clear. In this paper, its chem. constituents and their anti-inflammatory activities were investigated. As results, ten compounds, named as imperphenoside A (1), imperphenols B (2) and C (3), imperphenosides D-F (4-6), and imperlignanosides A-D (7-10), along with previously reported thirty-seven known ones (11-47) were obtained from it. Their structures were ascertained basing on the extensive spectroscopic methods and electronic CD data anal. Meanwhile, compounds 4, 11, 12, 24, 27, 31, 32, 37, 43, 45, and 47 exhibited nitric oxide inhibitory effects in concentration dependent at 3, 10, and 30 μM on lipopolysaccharides induced RAW 264.7 cells. Moreover, the western blot anal. indicated that compounds 4, 11, 43, and 47 could restrain the phosphorylation of nuclear factor kappa-B kinase to down-regulate the protein expression of inflammatory cytokines such as inducible nitric oxide synthase, interleukin-6 and tumor necrosis factor-α. In conclusion, they might play the anti-inflammatory effects through regulating NF-κB signaling pathway.

Phytochemistry (Elsevier) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Zheng published the artcileSteam-Assisted in Situ Prepared TS-1 with Hierarchical Pores and Tunable Acid Sites Grown on Carbon Nanotubes Decorated Nickel Foam, HPLC of Formula: 1589-47-5, the publication is Industrial & Engineering Chemistry Research (2020), 59(7), 2761-2772, database is CAplus.

The TS-1 particles grown on carbon nanotubes decorated nickel foam (denoted as MTS-1S) are successfully synthesized by a steam-assisted crystallization method that does not waste the gels and is more convenient, economical, and efficient than the traditional hydrothermal method. MTS-1S possesses a hierarchical porous structure of micropores, mesopores, and macropores and a high content of titanium in the skeleton, which is beneficial for the diffusion of reactants and products and exhibits excellent catalytic performance for the epoxidation of propylene. The impact of water on the formation of acid sites has been demonstrated by d. functional theory (DFT). The acid sites of MTS-1S can be tuned by controlling the amount of water at the bottom of autoclave during steam-assisted crystallization, which significantly increases the selectivity to propylene oxide. Finally, the impact of acid sites of Si-OH and Ti-OH groups (Ti located in a defect structure, adjacent to Si-OH) on the reaction of epoxidation of propylene is confirmed by simulation.

Industrial & Engineering Chemistry Research published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C14H10O4S2, HPLC of Formula: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sun, Guodong published the artcileOrganic matter biomarker and ¹³C NMR characteristics of soil and sediment standard reference materials from China, Formula: C9H10O4, the publication is Science of the Total Environment (2022), 155661, database is CAplus and MEDLINE.

Soil and sediment organic matter (OM) in terrestrial environments represent two critical organic carbon pools on Earth and are likely subject to distinct degrees of oxidation and modification. However, few studies have identified critical mol.-level characteristics that differentiate soil and sediment OM from various climate zones. Using biomarkers and solid-state ¹³C NMR (NMR) spectroscopy analyses, we studied the OM characteristics of 11 soil and 7 sediment standard reference materials (SRMs) originating from various geog. locations in China. Results showed significantly higher concentrations of lignin phenols in sediment OM than in soil OM, which may result from protection by higher contents of CaO and less microbial degradation in sediments. Nevertheless, the relative abundances of solvent-extractable lipids (alkanes, alkanols, and alkanoic acids) and ester-bound cutin and suberin biomarkers did not differ significantly between soil and sediment SRMs. The concentrations of lignin biomarkers decreased with increasing weathering degree of the soil, while cutin biomarkers increased with mean annual temperature and precipitation This phenomenon was not observed in sediment SRMs. This study reveals the distinct OM characteristics between Chinese soil and sediment SRMs and provides fundamental data for future studies to link OM characteristics and functions.

Science of the Total Environment published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C10H20O2, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ayehunie, Seyoum published the artcileOrganotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Toxicology in Vitro (2006), 20(5), 689-698, database is CAplus and MEDLINE.

A three-dimensional organotypic vaginal-ectocervical (VEC) tissue model has been developed to test the irritation of topically applied spermicides, microbicides, and vaginal-care products. The in vitro tissue model was reconstructed using normal VEC epithelial cells and is well stratified, containing differentiated basal, suprabasal, intermediate, and superficial cell layers similar to in vivo tissue. The intermediate and superficial cell layers contain glycogen, and the expression of cytokeratins 13 and 14 in the tissue also parallels that of native tissue. The MTT viability assay and histol. assessment were used to test inter-lot and intra-lot reproducibility. The MTT average intra-lot coefficient of variation (CV) was less than 10% and the time required to reduce tissue viability by 50% (ET-50) following application of 1% Triton X-100 averaged 1.25±0.24 h (n = 23) upon completion of the 11-day culture period and 1.30 h ± 0.19 for the same tissues stored overnight at 4° on agarose gels. The utility of the VEC model for irritation studies was examined by testing com. available products using the MTT assay and histol. assessment. The average ET-50 values ranged between 1.8 and 2.7 h for feminine washes, 3.9-6.7 h for spermicides, 6.8-18 h for anti-itch creams, and >18 h for douches, lubricants, and anti-fungal creams. Studies of cytokines released from VEC cultures following product application showed that elevated concentrations of IL-1α and IL-1β were associated with toxicity of test materials. In conclusion, the VEC tissue model is a highly reproducible, non-animal means to assess the irritation of contraceptives, microbicides, and vaginal-care products.

Toxicology in Vitro published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem