Month: December 2022

Das, Amrita published the artcileRh(I)-catalyzed imine-directed C-H functionalization via the oxidative [3+2] cycloaddition of benzylamine derivatives with maleimides, Application In Synthesis of 6850-57-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(8), 1123-1126, database is CAplus and MEDLINE.

The Rh(I)-catalyzed imine-directed oxidative [3+2] cycloaddition of benzylamines derivatives with maleimides for synthesis of pyrrolopyrroles I [R = Ph, 2-thienyl, cyclohexyl, etc.; R¹ = H, Me, Bn, etc.] was reported. A wide range of both benzylamines derivatives and maleimides was applicable to the reaction. A one-pot three component strategy using benzylamines, 2-pyridinecarboxaldehyde and maleimides was successfully achieved. Mechanistic studies including deuterium labeling experiments suggested that a zwitterionic intermediate was formed and was a key intermediate through the Rh-catalyzed activation of a benzylic C(sp³)-H bond of the imine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Das, Amrita published the artcileRh(II)-Catalyzed C-H Alkylation of Benzylamines with Unactivated Alkenes: The Influence of Acid on Linear and Branch Selectivity, HPLC of Formula: 6850-57-3, the publication is Organic Letters (2021), 23(11), 4273-4278, database is CAplus and MEDLINE.

The Rh-catalyzed C-H alkylation of benzylamine derivatives 2RC₆H₄CH₂NHC(O)R¹ (R = Me, methoxy, trifluoromethyl; R¹ = pyridin-2-yl) and I (X = H) with unactivated 1-alkenes R²HC=CH² (R² = pentyl, cyclohexylmethyl, 4-(acetyloxy)butyl, etc.) that proceeds via a picolinamide directing group is reported. The crucial role of an acid additive in this transformation is confirmed. Aromatic acids showed high linear selective products e.g., N-(2-heptyl-6-methylbenzyl)picolinamide, and aliphatic acids provided branched alkylation products e.g., N-(2-(hexan-2-yl)-6-methylbenzyl)picolinamide as the major product. The reaction has a broad scope for benzylamines and alkenes. Deuterium labeling experiments suggest that a Rh-carbene intermediate is involved in the case of linear product formation. A different reaction pathway, however, appears to be involved in the case of branched alkylation products, and this pathway also appeared to be a minor pathway in linear-selective reactions.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lee, Chang-Soo published the artcileA novel fluorescent nanoparticle composed of fluorene copolymer core and silica shell with enhanced photostability, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Colloids and Surfaces, B: Biointerfaces (2012), 219-225, database is CAplus and MEDLINE.

A variety of fluorescent nanoparticles have been developed for demanding applications such as optical biosensing and fluorescence imaging in live cells. Silica-based fluorescent nanoparticles offer diverse advantages for biol. applications. For example, they can be used as labeling probes due to their low toxicity, high sensitivity, resolution, and stability. In this research, a new class of highly fluorescent, efficient nanoparticles composed of a newly synthesized poly[di(2-methoxy-5-(2-ethylhexyloxy))-2,7-(9,9-dioctyl-9H-fluorene)] (PDDF) core and a silica shell (designated as PDDF@SiO₂) were prepared using a simple reverse micelle method, and their fluorescent properties were evaluated using methods such as single-dot photoluminescence measurements. The enhanced photostability of the particles and their potential applications for bioanal. are discussed in this article. The morphol., size, and fluorescent properties for prepared PDDF@SiO₂ nanoparticles were characterized using transmission electron microscopy (TEM), SEM (SEM) and photoluminescence spectroscopy. The prepared particles size, which was approx. 60 nm, resulted in an excellent colloidal stability in a physiol. environment. The photobleaching dynamics, total numbers of emitted photons (TNEP) and statistical measurements of individual nanoparticles were observed using laser scanning fluorescence microscopy to assess the structure and photostability of PDDF@SiO₂ nanoparticles. Addnl., PDDF@SiO₂ nanoparticles were used in cell toxicity and permeation tests for biol. analyses, demonstrating a great potential for use as powerful, novel materials within the emerging fields of biosensing and biomedical engineering.

Colloids and Surfaces, B: Biointerfaces published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Jia-Xin published the artcileNear-Linear Controllable Synthesis of Mesoporosity in Hierarchical UiO-66 by Template-Free Nucleation-Competition, SDS of cas: 1589-47-5, the publication is Advanced Functional Materials (2021), 31(30), 2102868, database is CAplus.

Hierarchies design of porosity in metal-organic frameworks (MOFs) has gained significant interest in recent years, and customization of mesoporous sizes in MOFs is still quite challenging. Herein, a template-free method by nucleation-competition has been developed to realize a near-linear control of the mesopore sizes (3-13 nm) in the hierarchical MOF UiO-66(Hf). High selectivity of enzyme adsorption, high activity of bulky-mol. catalysis, high stability of mesostructure, and extension to other MOFs further prove the success in the potential customization synthesis and applications.

Advanced Functional Materials published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ramachandran, P. Veeraraghavan published the artcileStudies towards the synthesis of epothilone A via organoboranes, Formula: C21H37BO, the publication is Organic & Biomolecular Chemistry (2005), 3(20), 3812-3824, database is CAplus and MEDLINE.

Studies towards the synthesis of epothilone A via organoboranes have been described. A modified procedure for the large-scale preparation of B-γ,γ-dimethylallyldiisopinocampheylborane from prenyl alc. has been developed. This reagent, upon reaction with various aldehydes RCHO (R = Et, Ph, 4-MeOC₆H₄CH₂OCH₂CH₂, etc.), provides the corresponding α,α-dimethylhomoallylic alcs. I in high enantioselectivities. The application of this reagent for the synthesis of the C₁-C₆ subunit II of epothilone has been demonstrated. Alternatively, inter- and intramol. asym. reduction protocols have also been utilized for the synthesis of the C₁-C₆ subunit of epothilone A. The synthesis of the C₇-C₂₁ fragment III of epothilone A involving asym. alkoxyallyl- and crotylboration using α-pinene-derived reagents has also been described.

Organic & Biomolecular Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Qingyu published the artcileHypervalent Chalcogenonium…π Bonding Catalysis, Synthetic Route of 93-04-9, the publication is Angewandte Chemie, International Edition, database is CAplus and MEDLINE.

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions.

Angewandte Chemie, International Edition published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C9H9BN2O2, Synthetic Route of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Qingyu published the artcileHypervalent Chalcogenonium…π Bonding Catalysis, Computed Properties of 91-16-7, the publication is Angewandte Chemie, International Edition, database is CAplus and MEDLINE.

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions.

Angewandte Chemie, International Edition published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C7H5Cl2NO, Computed Properties of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lui, Yuen Wai published the artcileMethylation with Dimethyl Carbonate/Dimethyl Sulfide Mixtures: An Integrated Process without Addition of Acid/Base and Formation of Residual Salts, COA of Formula: C11H10O, the publication is ChemSusChem (2022), 15(3), e202102538, database is CAplus and MEDLINE.

Di-Me sulfide, a major byproduct of the Kraft pulping process, was used as an inexpensive and sustainable catalyst/co-reagent (Me donor) for various methylations with di-Me carbonate (as both reagent and solvent), which afforded excellent yields of O-methylated phenols and benzoic acids, and mono-C-methylated arylacetonitriles. Furthermore, these products could be isolated using a remarkably straightforward workup and purification procedure, realized by di-Me sulfide’s neutral and distillable nature and the absence of residual salts. The likely mechanisms of these methylations were elucidated using exptl. and theor. methods, which revealed that the key step involves the generation of a highly reactive trimethylsulfonium methylcarbonate intermediate. The phenol methylation process represents a rare example of a Williamson-type reaction that occurs without the addition of a Bronsted base.

ChemSusChem published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lui, Yuen Wai published the artcileMethylation with Dimethyl Carbonate/Dimethyl Sulfide Mixtures: An Integrated Process without Addition of Acid/Base and Formation of Residual Salts, COA of Formula: C8H10O2, the publication is ChemSusChem (2022), 15(3), e202102538, database is CAplus and MEDLINE.

Di-Me sulfide, a major byproduct of the Kraft pulping process, was used as an inexpensive and sustainable catalyst/co-reagent (Me donor) for various methylations with di-Me carbonate (as both reagent and solvent), which afforded excellent yields of O-methylated phenols and benzoic acids, and mono-C-methylated arylacetonitriles. Furthermore, these products could be isolated using a remarkably straightforward workup and purification procedure, realized by di-Me sulfide’s neutral and distillable nature and the absence of residual salts. The likely mechanisms of these methylations were elucidated using exptl. and theor. methods, which revealed that the key step involves the generation of a highly reactive trimethylsulfonium methylcarbonate intermediate. The phenol methylation process represents a rare example of a Williamson-type reaction that occurs without the addition of a Bronsted base.

ChemSusChem published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lui, Matthew Y. published the artcileUnravelling Some of the Key Transformations in the Hydrothermal Liquefaction of Lignin, Synthetic Route of 183303-74-4, the publication is ChemSusChem (2017), 10(10), 2140-2144, database is CAplus and MEDLINE.

Using both exptl. and computational methods, focusing on intermediates and model compounds, some of the main features of the reaction mechanisms that operate during the hydrothermal processing of lignin were elucidated. Key reaction pathways and their connection to different structural features of lignin were proposed. Under neutral conditions, subcritical water was demonstrated to act as a bifunctional acid/base catalyst for the dissection of lignin structures. In a complex web of mutually dependent interactions, guaiacyl units within lignin were shown to significantly affect overall lignin reactivity.

ChemSusChem published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, Synthetic Route of 183303-74-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem