Month: December 2022

Wojcik-Pszczola, Katarzyna published the artcilePan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation, Application In Synthesis of 6850-57-3, the publication is Pharmaceuticals (2022), 15(4), 423, database is CAplus and MEDLINE.

Airway remodeling is a pathol. process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in The remodeling process by increasing extracellular matrix secretion, acquiring migration properties, and overproducing pro-fibrotic transducers. Here, we investigated the effect of three new 8-arylalkylamino- and 8-alkoxy-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl-N-(5-(tertbutyl)-2-hydroxyphenyl)butanamides (1, 2, and 3), representing prominent pan-phosphodiesterase (pan-PDE) inhibitors on transforming growth factor type β (TGF-β)-induced alveolar epithelial type II cells (A549 cell line) of a pro-fibrotic phenotype. Our results demonstrate for the first time the strong activity of pan-PDE inhibitors in the prevention of TGF-β-induced mesenchymal markers′ expression and A549 cells′ migration. We also showed an increased p-CREB and decreased p-Smad-2 phosphorylation in TGF-β-induced A549 cells treated with 1, 2, and 3 derivatives, thereby confirming a pan-PDE inhibitor mesenchymal phenotype reducing effect in alveolar epithelial type II cells via suppression of the canonical Smad signaling pathway. Our observations confirmed that PDE inhibitors, and especially those active against various isoforms involved in the airway remodeling, constitute an interesting group of compounds modulating the pro-fibrotic response of epithelial cells.

Pharmaceuticals published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H16O3, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vladimirtsev, I. F. published the artcilePreparation and biological activity of some thiourea derivatives, Computed Properties of 14807-75-1, the publication is Fiziologicheski Aktivnye Veshchestva (1966-1992) (1975), 120-3, database is CAplus.

H2NC(:NH)SO2H (I) reacted with aqueous HCl at 60-70° to give 37.8% S2[C(:NH)NH2.HCl]2 (II), which reacted with NaOEt to give 100% S, 95% thiourea (III), and 77% S[C(:NH)NH2.HCl]2 (IV). Urea, I, IV, and H2NC(:NH)S(O)SC(:NH)NH2.2H2O inhibited the growth of lettuce, oat, and cucumber sprouts at 0.01%, but stimulated growth at 0.0001%; the opposite effect was observed with III.

Fiziologicheski Aktivnye Veshchestva (1966-1992) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C4H10Br2CoO2, Computed Properties of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chang, Hson Mou published the artcileStructure elucidation and total synthesis of new tanshinones isolated from Salvia miltiorrhiza Bunge (Danshen), HPLC of Formula: 2944-47-0, the publication is Journal of Organic Chemistry (1990), 55(11), 3537-43, database is CAplus.

Eleven new compounds were isolated from the dried root of Salvia miltiorrhiza Bunge “Danshen”, and their structures were elucidated by spectrometric methods. The total syntheses of 2 new compounds namely, 1,2-didehydromiltirone (I) and 4-methylenemiltirone (II) are also reported.

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, HPLC of Formula: 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Wen-Pei published the artcileAcid-Free Copper-Catalyzed Electrophilic Nitration of Electron-Rich Arenes with Guanidine Nitrate, Recommanded Product: 2-Methoxynaphthalene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32%-99%) at ambient temperature under acid free, open-flask and operationally simple conditions.

Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Wen-Pei published the artcileAcid-Free Copper-Catalyzed Electrophilic Nitration of Electron-Rich Arenes with Guanidine Nitrate, HPLC of Formula: 91-16-7, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32%-99%) at ambient temperature under acid free, open-flask and operationally simple conditions.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pan, Jiang-Qing published the artcileSynthesis and characterization of fully soluble polyphenylenevinylene, SDS of cas: 146370-51-6, the publication is Chinese Journal of Polymer Science (2000), 18(6), 541-549, database is CAplus.

Fully soluble poly[2-(2-ethylhexyloxy)-5-methoxy-p-phenylenevinylene] was synthesized by the polymerization of 2-(2-ethylhexyloxy)-5-methoxy-1,4-xylylene dibromide with addition of mol. weight modifiers (chain stopper, free radical scavengers) to a polymerization system containing monomer, catalyst, and solvent. The polymers synthesized in this work were characterized by IR, NMR, and UV-visible spectroscopy, and gel-permeation chromatog. Results show that the weight-average mol. weight of the polymer can be controlled by the addition of chain stopper (benzyl bromide) and radical inhibitor (BHT). The polymerization mechanism in the presence of these additives was also discussed. A dual mechanism involving carbene for the polymerization was proposed.

Chinese Journal of Polymer Science published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, SDS of cas: 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yao, Juanjuan published the artcileNew insight into the regulation mechanism of visible light in naproxen degradation via activation of peroxymonosulfate by MOF derived BiFeO₃, Application of 2-Methoxynaphthalene, the publication is Journal of Hazardous Materials (2022), 128513, database is CAplus and MEDLINE.

BiFeO₃ (BFO) nanocage prepared by metal-organic-framework derivatization (MOF-d) was adopted as activator to first investigate the effect mechanism of visible-light on naproxen-degradation via peroxymonosulfate (PMS) activation. MOF-d BFO expressed more excellent PMS activation ability than hydrothermal-synthetic BFO, due to highly ordered mesopores. A 3.0 times higher pseudo-first-order degradation rate constant was achieved after visible-light introduced. The quenching experiments indicated that the contribution of ROS in naproxen degradation followed the order of SO•^–₄>¹O₂ ≈ •OH in MOF-d BFO/PMS/dark system, while changed into h⁺>¹O₂ > >O•-app2SO•^–₄> •OH after visible-light introduced. EPR tests first revealed that visible-light promoted ¹O₂ yield (non-radical pathway) but suppressed •OH and SO•^–₄ generation (free-radical pathways). N2-purging experiments further proved that ¹O₂ primarily originates from the reaction between h⁺ and PMS, equivalently to that between O₂ and e^–-h⁺ in MOF-d BFO/PMS/vis system. Under visible-light, PMS activation via Fe (III) might be hindered by e- filling on Fe 3d orbital and anion PMS preferred to approach h⁺ rather than e^–, resulting in the decrease of •OH and SO•^–₄ yields. Moreover, PMS faces competition from adsorbed-O₂ and oxygen-vacancies for e^– capture. The degradation-pathways for naproxen in dark and under visible light were both proposed in MOF-d BFO/PMS system.

Journal of Hazardous Materials published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C22H38O2, Application of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhou, Yu-Xiao published the artcileMIL-101-SO₃H: A Highly Efficient Bronsted Acid Catalyst for Heterogeneous Alcoholysis of Epoxides under Ambient Conditions, SDS of cas: 1589-47-5, the publication is Chemistry – A European Journal (2014), 20(46), 14976-14980, database is CAplus and MEDLINE.

For the first time, a ∼100% sulfonic acid functionalized metal-organic framework (MOF), MIL-101-SO₃H, with giant pores (macroporous material) has been prepared by a hydrothermal process followed by a facile postsynthetic hydrochloric acid (HCl) treatment strategy. The replete readily accessible Lewis acidic and especially Bronsted acidic sites distributed throughout the framework as well as high stability endow the resultant MOF exceptionally high efficiency and recyclability, which surpass all other MOF-based catalysts, for the ring opening of epoxides with alcs. (especially, methanol) as nucleophiles under ambient reaction conditions. The synthesis of the target compound (catalyst) was achieved using chromium oxide (CrO₃) with 2-sulfo-1,4-benzenedicarboxylic acid sodium salt [i.e., 2-sulfoterephthalic acid monosodium salt] as reactants. Oxirane starting materials included 2-(phenyl)oxirane, 2-(methyl)oxirane, 2-(chloromethyl)oxirane, 2-oxiranemethanol and 2,2-dimethyl(epoxide). Regioselective ring-opening reaction products with alcs. included β-(methoxy)benzeneethanol, β-(ethoxy)benzeneethanol, β-(propoxy)benzeneethanol, β-(1,1-dimethylethoxy)benzeneethanol, 2-methoxy-1-propanol, 2-ethoxy-1-propanol, 2-propoxy-1-propanol and related compounds (primary alcs.). Secondary alcs. were also formed.

Chemistry – A European Journal published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C19H14O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xiong, Ying published the artcileEnantioselective Total Synthesis of (-)-Hamigeran F and Its Rearrangement Product, Application In Synthesis of 725251-81-0, the publication is Organic Letters (2022), 24(28), 5161-5165, database is CAplus and MEDLINE.

Herein, we report the first enantioselective total synthesis of the highly complex hamigeran diterpenoid (-)-hamigeran F and its rearrangement product. The synthetic strategy features key steps of asym. hydrogenation, Horner-Wadsworth-Emmons olefination, and intramol. Friedel-Crafts acylation to construct the [6,6,5]-tricyclic skeleton bearing three consecutive stereocenters, a sequence of steps involving Rosenmund reduction, Wittig reaction, dihydroxylation to assemble the α-acetoxy ketone group, and an intramol. aldol reaction to build the tetracyclic core structure.

Organic Letters published new progress about 725251-81-0. 725251-81-0 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Methoxy-5-methylphenyl)boronic acid, and the molecular formula is C18H23N3O4S, Application In Synthesis of 725251-81-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Ying-Qi published the artcileAsymmetric dearomatization catalysed by chiral Bronsted acids via activation of ynamides, Category: ethers-buliding-blocks, the publication is Nature Chemistry (2021), 13(11), 1093-1100, database is CAplus and MEDLINE.

The chiral Bronsted acids enable the catalytic asym. dearomatization reactions of naphthols- phenols- RCCN(R¹)R² (R = 2-(4-hydroxynaphthalen-1-yl)benzen-1-yl, 2-(4-hydroxy-1,4,5,6,7,8-hexahydronaphthalen-1-yl)benzen-1-yl, 2-(2-hydroxyphenyl)benzen-1-yl, etc.; R¹ = Ms, Ts, Bs, etc.; R² = Ph, naphthalen-2-yl, n-Bu, etc.) and pyrrole-ynamides R³(CH₂)₂NCC(R¹)R² (R³ = 2,5-dimethyl-1H-pyrrol-1-yl, 2-methyl-5-(thiophen-3-yl)-1H-pyrrol-1-yl, 2-methyl-5-phenyl-1H-pyrrol-1-yl, etc.) by the direct activation of alkynes. This method leads to the practical and atom-economic construction of various valuable spirocyclic enones I (R⁴ = H, 6-F, benzene-1,2-bis(yl), 5-Cl, etc.) and II, 2H-pyrroles III (R⁵ = Me, Ph, thiophen-2-yl, etc.; R⁶ = Me, Et) that bear a chiral quaternary carbon stereocenter in generally good-to-excellent yields with excellent chemo-, regio- and enantioselectivities. The activation mode of chiral Bronsted acid catalysis revealed in this study is expected to be of broad utility in catalytic asym. reactions that involve ynamides and the related heteroatom-substituted alkynes.

Nature Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem