Month: December 2022

Hyper-Crosslinked Porous Chiral Phosphoric Acids: Robust Solid Organocatalysts for Asymmetric Dearomatization Reactions was written by Huang, Xian-Yun;Zheng, Qingshu;Zou, Lei-Ming;Gu, Qing;Tu, Tao;You, Shu-Li. And the article was included in ACS Catalysis in 2022.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Knitting rigid aromatic building blocks using external crosslinkers has been developed into an effective strategy for the synthesis of porous polymers in recent years. Here, the authors report the synthesis of porous chiral phosphoric acids by this strategy. Moreover, these porous chiral phosphoric acids were found to enable highly enantioselective dearomatization reactions. Remarkably, after being reused for 10 runs, no obvious loss in catalytic activity and selectivity was observed The features of high reactivity, selectivity, stability, and recyclability of these hyper-crosslinked porous chiral phosphoric acids are significant for practical catalyst design. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Molecular Orbital Calculation for the Model Compounds of Kainoid Amino Acids, Agonists of Excitatory Amino Acid Receptors. Does the Kainoid C4-Substituent Directly Interact with the Receptors? was written by Hashimoto, Kimiko;Matsumoto, Takatoshi;Nakamura, Kensuke;Ohwada, Shu-ichi;Ohuchi, Tatsuro;Horikawa, Manabu;Konno, Katsuhiro;Shirahama, Haruhisa. And the article was included in Bioorganic & Medicinal Chemistry in 2002.Safety of 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:

Kainoid amino acids are agonists of the AMPA/kainate receptors and exhibit highly potent neuroexcitatory activity. From the results of extensive structure-activity relationship studies, we previously postulated that the C4-substituent of the kainoid amino acids interacts with an allosteric site of the glutamate receptor with electron-donating character. In order to investigate the mode of action in more detail, MO calculation for model compounds of the kainoid were performed. The results indicated that the HOMO energy level of the C4-substituent is involved in the potent neuroexcitatory activity, thus supporting our hypothesis. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Safety of 4-Iodo-1-methoxy-2-methylbenzene).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 4-Iodo-1-methoxy-2-methylbenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Modeling of physico-chemical properties by topological indices was written by Katona, G.;Panea, Teodora. And the article was included in Acta Universitatis Cibiniensis, Seria F: Chemia in 2005.Recommanded Product: 1877-75-4 This article mentions the following:

A study of the quant. structure-property and structure-activity relationship QSPR/QSAR is presented for a set of aryloxyacetic acid derivatives Some QSAR properties were also calculated and correlated with topol. descriptors. As mol. descriptors the Cluj and Cluj type, Szeged and some classical indexes were used. Cluj and Szeged properties indexes considering the electronegativity, mass and 3D-geometry were also used. Some models for predicting LogP, hydration energy and Ka of the above set of acids are proposed. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Impact of Side Chain Chemistry on Lithium Transport in Mixed Ion-Electron-Conducting Polymers was written by Pace, Gordon;Nordness, Oscar;Asham, Kareem;Clement, Raphaele J.;Segalman, Rachel A.. And the article was included in Chemistry of Materials in 2022.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

Typical design strategies for mixed ion-electron conduction in polymers have focused on overall ionic conductivity, without specificity for anion vs cation conduction. Here, we demonstrate that side chain chem. can be used to control Li⁺ conductivity in semiconducting polymers. This design principle is significant for applications that require Li⁺-specific transport, such as Li-ion batteries. We show that a polythiophene functionalized with an ionic liquid side chain demonstrates higher conductivity and lithium transference than a more commonly studied ether-functionalized P3AT derivative Poly(3-(6′-(N-methylimidazolium) hexyl)thiophene TFSI^–) (P3HT-Im⁺TFSI^–) can solvate and conduct ions up to salt concentrations of r = 1.0 (where r = [moles of salt]/[moles of monomer]) while achieving an ionic conductivity of ~10^-3 S/cm at 80°C and a lithium transference number of 0.36. On the other hand, poly(3-(methoxyethoxyethoxymethyl)thiophene) (P3MEEMT) shows a peak conductivity of ~10^-5 S/cm at r = 0.05 and 80°C, with near-zero lithium transport. This work shows that multiple high dielec. moieties can be used to drive ion conduction in semiconducting polymers, but diffuse, cationic side chains such as imidazolium are preferred for Li-ion conduction. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cycloaddition of Enamines with 1,4-Dimethoxy-2-butyne and 2-Butyne-1,4-diol Mediated by Titanium Tetrachloride was written by Uludag, Nesimi;Yarapsanli, Yesim;Asutay, Oktay;Gumus, Mustafa Kemal. And the article was included in Organic Preparations and Procedures International in 2018.Synthetic Route of C6H10O2 This article mentions the following:

[2 + 2]-Cycloaddition of 1,4-dimethoxy-2-butyne with, e.g., 1-morpholinocyclohexene afforded cyclobutene I when the reaction was conducted below 0° in toluene; subsequent reflux in toluene afforded the ring-expanded II. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Synthetic Route of C6H10O2).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Synthetic Route of C6H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Methods for Preparing Metal Ion Photocages: Application to the Synthesis of CrownCast was written by Kennedy, Daniel P.;Gwizdala, Celina;Burdette, Shawn C.. And the article was included in Organic Letters in 2009.HPLC of Formula: 66943-05-3 This article mentions the following:

Three different synthetic strategies were utilized in the construction of a representative of a novel class of macrocyclic containing o-nitrobenzhydrol group II cation cages I (X = 1-aza-15-crown-5). The binding properties of I and its photoproduct II to several alk. earth metal cations have been studied. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium-catalyzed oxidative coupling of N-acyl anilines with alkynes using an acylamino moiety as the traceless directing group was written by Geng, Kaijun;Fan, Zhoulong;Zhang, Ao. And the article was included in Organic Chemistry Frontiers in 2016.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

A rhodium-catalyzed oxidative annulation of N-acyl anilines with alkynes was developed by using the acylamino group as a traceless directing group for the first time. Various N-acyl anilines and para- or meta-substituted diphenylacetylenes were well tolerated, and a series of 1,2,3,4-tetrasubstituted naphthalenes were readily synthesized in good to excellent yields. Meanwhile, this method also provided a new strategy for the N-dearylation of N-phenylamides. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

High nitrogen content carbons: Morphological and chemical changes with synthesis temperature and application in lithium-sulfur batteries was written by Arias, Analia Natali;Villarroel-Rocha, Jhonny;Sapag, Karim;Mori, Maria Fernanda;Planes, Gabriel Angel;Tesio, Alvaro Yamil;Flexer, Victoria. And the article was included in Electrochimica Acta in 2020.Application In Synthesis of 2,5,8,11-Tetraoxadodecane This article mentions the following:

The authors present a new two-step synthesis method to prepare N-doped carbons with micro, meso and macroporosity. The authors modified the classical polycondensation of resorcinol-formaldehyde, by adding a large excess of melamine in basic medium. Materials were prepared by varying the maximum carbonization temperature in the range 600-900°, and are denoted NCC-X, where X denotes that maximum temperature NCC-X showed a high N content, ranging from 32.9% to 10.3%. SEM showed macropores in the order of 100-600 nm, with sizes decreasing with temperature, reaching a min. for NCC-800, and then increasing again. N₂ adsorption-desorption isotherms showed micro and mesopores for all samples, with a maximum surface area of 505 m² g^-1 for NCC-800. CO₂ adsorption isotherms showed that all NCC-X materials present ultramicropores. NCC-X were incorporated as host materials for elemental S in Li-S batteries. The increased narrow micropore volume of materials pyrolyzed at higher temperature seems to promote an initial higher cell capacity. Conversely, the much higher N content and the higher amount of N in pyridinic environments were identified as the reasons for the higher cycling stability of the cells prepared with NCC-600-7h and NCC-750. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application In Synthesis of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Aerobic Oxidation Catalysis of Mesoporous Todorokite-Type Manganese Oxide Nanoparticles by Crystallization of Precursors was written by Koutani, Maki;Hayashi, Eri;Kamata, Keigo;Hara, Michikazu. And the article was included in Journal of the American Chemical Society in 2022.Safety of (4-Methoxyphenyl)methanol This article mentions the following:

The pursuit of a high surface area while maintaining high catalytic performance remains a challenge due to a trade-off relationship between these two features in some cases. In this study, mesoporous todorokite-type manganese oxide (OMS-1) nanoparticles with high sp. surface areas were synthesized in one step by a new synthesis approach involving crystallization (i.e., solid-state transformation) of a precursor produced by a redox reaction between MnO₄^– and Mn²⁺ reagents. The use of a low-crystallinity precursor with small particles is essential to achieve this solid-state transformation into OMS-1 nanoparticles. The sp. surface area reached up to ca. 250 m² g^-1, which is much larger than those (13-185 m² g^-1) for Mg-OMS-1 synthesized by previously reported methods including multistep synthesis or dissolution/precipitation processes. Despite ultrasmall nanoparticles, a linear correlation between the catalytic reaction rates of OMS-1 and the surface areas was observed without a trade-off relationship between particle size and catalytic performance. These OMS-1 nanoparticles exhibited the highest catalytic activity among the Mn-based catalysts tested for the oxidation of benzyl alc. and thioanisole with mol. oxygen (O₂) as the sole oxidant, including highly active β-MnO₂ nanoparticles. The present OMS-1 nanomaterial could also act as a recyclable heterogeneous catalyst for the aerobic oxidation of various aromatic alcs. and sulfides under mild reaction conditions. The mechanistic studies showed that alc. oxidation proceeds with oxygen species caused by the solid, and the high surface area of OMS-1 significantly contributes to an enhancement of the catalytic activity for aerobic oxidation In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Safety of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Comparative analysis of the PET and ICT sensor properties of 1,8-naphthalimides containing aza-15-crown-5 ether moiety was written by Panchenko, Pavel A.;Fedorov, Yuri V.;Fedorova, Olga A.;Jonusauskas, Gediminas. And the article was included in Dyes and Pigments in 2013.Reference of 66943-05-3 This article mentions the following:

Novel 4-amino- and 4-(acetyl)amino-N-aryl-1,8-naphthalimides containing aza-15-crown-5 ether receptor unit in the N-aryl fragment and at C-4 of the naphthalimide residue were designed and prepared Significant internal charge transfer from electron donating amino or amido group at C-4 of the naphthalene ring to the acceptor carboxyimide moiety as well as photoinduced electron transfer between N-aryl receptor and the naphthalimide fragment was revealed by the UV/Vis absorption spectroscopy and considerable fluorescence quenching. The addition of calcium perchlorate to an acetonitrile solution of naphthalimides with the receptor at imide nitrogen hindered the photoinduced electron transfer process and accordingly restored the quenched fluorescence of the free ligands. In the case of the compound in which the aza-15-crown-5 receptor is located at C-4, the coordination with Ca²⁺ reduced the internal charge transfer interaction in the chromophore and caused a significant blue-shift of the absorption and emission peak. The observed spectral effects were analyzed using PM6 semiempirical calculations Formation of complexes was also confirmed by ¹H NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Reference of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem