Palladium-catalyzed amination in the synthesis of aza- and diazacrown trismacrocyclic compounds was written by Yakushev, A. A.;Anokhin, M. V.;Averin, A. D.;Maloshitskaya, O. A.;Beletskaya, I. P.. And the article was included in Russian Chemical Bulletin in 2012.Product Details of 66943-05-3 This article mentions the following:
Palladium-catalyzed C-N-cross-coupling of N,N’-bis(bromobenzyl) diazacrown compounds with two equivalent of 1-aza-15-crown-5 and 1-aza-18-crown-6 ethers furnished trismacrocyclic compounds with isolated macrocycles. Macrotricyclic cryptands were obtained when diazacrown ethers were used as N-components. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Product Details of 66943-05-3).
1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Product Details of 66943-05-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem