Catalyst-Free α-Alkylation-α-Hydroxylation of Oxindole with Alcohols was written by Wu, Siwei;Song, Wei;Zhu, Runyu;Hu, Jingwen;Zhao, Lin;Li, Zheyao;Yu, Xinhong;Xia, Chengcai;Zhao, Jianhong. And the article was included in Journal of Organic Chemistry in 2022.Name: (4-Methoxyphenyl)methanol This article mentions the following:
A green and economical protocol for the synthesis of 3-alkyl-3-hydroxyoxindoles I [R1 = H, 6-Cl, 6-Br, etc.; R2 = Ph, 2-ClC6H4, 2-pyridyl, etc.] was developed for the first time via α-alkylation-α-hydroxylation of oxindole with aryl alcs. without using any transition-metal catalysts in yields of 29-93%. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Name: (4-Methoxyphenyl)methanol).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: (4-Methoxyphenyl)methanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem