Benzylpiperazine derivatives. VI. Design and syntheses of vinylogs of 1-benzyl-4-diphenylmethylpiperazine derivatives and their cerebral vasodilating activities was written by Ohtaka, Hiroshi;Kanazawa, Toshiro;Ito, Keizo;Tsukamoto, Goro. And the article was included in Chemical & Pharmaceutical Bulletin in 1987.HPLC of Formula: 6972-61-8 This article mentions the following:
Based on previous quant. structure-activity relationship (QSAR) results on cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazines, 1–cinnamyl-4-diphenylmethylpiperazines I (R = H, MeO; R1 = H, F), having electron-donating groups on the cinnamyl moiety, were designed. Two methods of synthesis are reported. Thus, 2,3,4-(MeO)3C6H2CH:CHCO2H was treated sequentially with Et3N, ClCO2Et and then bis(fluorophenyl)methylpiperazine (II) in Me3COH-MeCN to give the [bis(fluorophenyl)methyl](trimethoxycinnamoyl)piperazine III. Reducing III with NaAlH2(OCH2CH2OMe)2 gave 56% I (R = MeO, R1 = F). As expected from the QSAR results, these compounds exhibited stronger potency and longer-lasting effects than cinnarizine and flunarizine. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 6972-61-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem