Side-product in methylation of 2′,4”-O-bis (trimethylsilyl) erythromycin A 9-O-(1-isopropoxycyclohexyl) oxime was written by Liang, Jianhua;Yao, Guowei. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2006.Related Products of 1132-95-2 This article mentions the following:
A side-product of methylation was identified and the influence of the reaction condition on it was investigated. The side-product was E-2′-O-trimethylsilyl-6-O-methylerythromyein A 9-O-(1-isopropoxyeyelohexyl) oxime (1). Higher temperature, longer reaction time, the addition of triethylamine, and an excessive deproton reagent would lead to the increase of 1, whereas the order of adding methylating reagents followed by deproton reagents, an excessive methylating reagent, the mixture of tetrahydrofuran/dimethyl sulfoxide (THF/DMSO) and toluene/DMSO are detrimental to the production of 1. By optimizing the reaction condition, the yield of the methylation was 100.2% with 0.76% of 1. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Related Products of 1132-95-2).
1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 1132-95-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem