Palladium-catalyzed direct ortho-alkynylation of arylalkylacid derivatives at γ and δ positions via an N,O-bidentate directing group was written by Li, Guobao;Liu, Pei;Zhang, Jingyu;Shi, Da-Qing;Zhao, Yingsheng. And the article was included in Organic Chemistry Frontiers in 2017.Safety of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
Palladium-catalyzed ortho-alkynylation of arylalkylacid derivatives at remote γ and δ positions with the assistance of an N,O-bidentate directing group of glycine dimethylamide (GDMA) is reported for the first time. A wide variety of phenylacetic acid and 3-phenylpropionic acid derivatives is tolerated in this protocol, which provides a general means to synthesize substituted alkynylarylalkyl acid derivatives, e.g., I. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Safety of 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem