Molecular Orbital Calculation for the Model Compounds of Kainoid Amino Acids, Agonists of Excitatory Amino Acid Receptors. Does the Kainoid C4-Substituent Directly Interact with the Receptors? was written by Hashimoto, Kimiko;Matsumoto, Takatoshi;Nakamura, Kensuke;Ohwada, Shu-ichi;Ohuchi, Tatsuro;Horikawa, Manabu;Konno, Katsuhiro;Shirahama, Haruhisa. And the article was included in Bioorganic & Medicinal Chemistry in 2002.Safety of 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:
Kainoid amino acids are agonists of the AMPA/kainate receptors and exhibit highly potent neuroexcitatory activity. From the results of extensive structure-activity relationship studies, we previously postulated that the C4-substituent of the kainoid amino acids interacts with an allosteric site of the glutamate receptor with electron-donating character. In order to investigate the mode of action in more detail, MO calculation for model compounds of the kainoid were performed. The results indicated that the HOMO energy level of the C4-substituent is involved in the potent neuroexcitatory activity, thus supporting our hypothesis. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Safety of 4-Iodo-1-methoxy-2-methylbenzene).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 4-Iodo-1-methoxy-2-methylbenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem