(2-Piperidine)- and (2-pyrrolidine)ethanones and -ethanols as inhibitors of blood platelets aggregation was written by Grisar, J. Martin;Claxton, George P.;Stewart, Kenneth T.;MacKenzie, Robert D.;Kariya, Takashi. And the article was included in Journal of Medicinal Chemistry in 1976.Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:
RMI 14133A [(E)-4-[4-(methylthio)phenyl]-1-(2-piperidinyl)-3-buten-2-one-HCl](I) [59999-96-1] inhibited ADP-induced aggregation of blood platelets. I was selected from a large series of (2-piperidinyl)- and (2-pyrrolidinyl)ethanones synthesized by a modified Schoepf reaction from enolate Mg salts of β-keto acids and 2,3,4,5-tetrahydropyridine trimer [27879-53-4] or 3,4-dihydro-2H-pyrrole trimer [54564-48-6], resp. Subacute toxicity evaluation in dogs and guinea pigs showed I to have an unfavorable therapeutic ratio. RMI 12436A [1-[4′-chloro(1,1′-biphenyl)-4-yl]-2-(2-piperidinyl)ethanone-HCl](II) [54916-69-7] lowered serum cholesterol [57-88-5] levels in rats with concurrent accumulation of (3β)-cholesta-5,7-dien-3-ol [434-16-2], suggesting inhibition of 7-dehydrocholesterol Δ7-reductase [9080-21-1]. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).
1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem