Enamines. Part III. A new synthesis of substituted 2-arylisatogens and o-nitrophenyl benzyl ketones was written by Bhamare, N. K.;Kamath, H. V.;Kulkarni, Sheshgiri N.. And the article was included in Indian Journal of Chemistry in 1986.Recommanded Product: 5367-32-8 This article mentions the following:
The (nitrobenzoyl)morpholinostyrenes I [R, R1, R2 = 4-NO2, H, H; 4-NO2, H, 5-MeO; 2-NO2, 5-MeO, H; 4-NO2, H, 4,5-(MeO)2], prepared from the corresponding morpholinostyrene and o-nitrobenzoyl chloride, were hydrolyzed to give the o-nitrophenyl benzyl ketones II. I and II underwent cyclodehydration with AcONa/EtOH to give the isatogens III. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Recommanded Product: 5367-32-8).
3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 5367-32-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem