Blanpin, Odette published the artcileThe local-anesthetic action of pramoxine hydrochloride (tronothane, Related Products of ethers-buliding-blocks, the publication is Anesthesie, Analgesie, Reanimation (1957), 225-31, database is CAplus.
Pramoxine (or tronothane) is p-butoxyphenyl morpholinopropyl ether-HCl (I). Its pharmacol. properties and toxicity are reported. L.D.50 (intravenous injection into caudal vein of the mouse) 132 mg./kg.; L.D.min. (slow intravenous infusion in guinea pigs) 108.7 ± 2.3 mg./kg.; L.D.50 (subcutaneous injection into the mouse) 1.47 g./kg. A 1% solution of I was used to determine its local tolerance (in the eye of a rabbit) and its effectiveness as a local anesthetic (also on rabbits). I was found to be 3.6 times as effective as cocaine-HCl when used as a local anesthetic on the skin surface and 1.5 times as effective as procaine-HCl (II) in infiltration tests on guinea pigs. In tests determining the reduction of the excitability of a frog muscle preparation (sciatic nerve to the gastrocnemius muscle in Ringer solution, pH 6) a 0.10% solution of I had about the same effect as a 0.01% solution of II. I is, therefore, an excellent surface anesthetic, but its use in eye surgery must be rigorously avoided because of its property of producing necrosis of the mucous membrane and muscle fibers.
Anesthesie, Analgesie, Reanimation published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
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