Yan, Li-Mei published the artcileSelectively N-Methylated Soluble IAPP Mimics as Potent IAPP Receptor Agonists and Nanomolar Inhibitors of Cytotoxic Self-Assembly of Both IAPP and Aβ40, Product Details of C25H23NO4, the publication is Angewandte Chemie, International Edition (2013), 52(39), 10378-10383, database is CAplus and MEDLINE.
The aggregation of islet amyloid polypeptide (IAPP) is linked to β-cell degeneration and the pathogenesis of type 2 diabetes (T2D). IAPP is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP amyloid deposits are found in the pancreata of many T2D patients. In its soluble form, however, IAPP acts as a brain-gut neuropeptide regulator of glucose homeostasis. Here we show that selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40.
Angewandte Chemie, International Edition published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C5H9IO2, Product Details of C25H23NO4.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem