Moldovan, Rares-Petru's team published research in Journal of Medicinal Chemistry in 59

Moldovan, Rares-Petru published the artcileDevelopment of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor, SDS of cas: 1589-47-5, the publication is Journal of Medicinal Chemistry (2016), 59(17), 7840-7855, database is CAplus and MEDLINE.

Cannabinoid receptors type 2 (CB₂) represent a target with increasing importance for neuroimaging due to its upregulation under various pathol. conditions. Encouraged by preliminary results obtained with [¹¹C](Z)-N-(3-(2-methoxyethyl)-4,5-dimethylthiazol-2(3H)-ylidene)-2,2,3,3-tetramethyl-cyclopropanecarboxamide ([¹¹C]A-836339, [¹¹C]1) in a mouse model of acute neuroinflammation (induced by lipopolysaccharide, LPS), we designed a library of fluorinated analogs aiming for an [¹⁸F]-labeled radiotracer with improved CB₂ binding affinity and selectivity. Compound (Z)-N-(3-(4-fluorobutyl)-4,5-dimethylthiazol-2(3H)-ylidene)-2,2,3,3-tetramethyl-cyclopropanecarboxamide (29) was selected as the ligand with the highest CB₂ affinity (K_i = 0.39 nM) and selectivity over those of CB₁ (factor of 1000). [¹⁸F]29 was prepared starting from the bromo precursor (53). Specific binding was shown in vitro, whereas fast metabolism was observed in vivo in CD-1 mice. Animal PET revealed a brain uptake comparable to that of [¹¹C]1. In the LPS-treated mice, a 20-30% higher uptake in brain was found in comparison to that in nontreated mice (n = 3, P < 0.05).

Journal of Medicinal Chemistry published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem